RCBTB2 and COPS4

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		RCBTB2	COPS4
Name		RCC1 and BTB domain containing protein 2	COP9 signalosome subunit 4
Structure		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction Cytoplasmic Vesicle Protein-containing Complex Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding DeNEDDylase Activity
	Biological Process	Liver Development Cell Population Proliferation Lymph Node Development Spleen Development Digestive Tract Development	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		None	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
GWAS		Metabolite levels ( 23823483 )	Metabolite levels ( 23823483 )
Interacting Genes		8 interacting genes: COPS4 FARS2 MORF4L1 PDE4B PLA2G6 RBBP9 TMEM132D UBE2I	28 interacting genes: BRME1 CCDC85B CEBPA COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 DSCR9 FOS GPS1 HUNK IKBKB IL1RN KRT19 LCOR MBIP PCDHB12 PEX14 RAB18 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		1102	51138
HPRD ID		04631	09888
Ensembl ID		ENSG00000136161	ENSG00000138663
Uniprot IDs		B4DWG0 B4E372 O95199 Q59FB7	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs		Not available	4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F
GO Terms Enriched among Interactors		Serine Hydrolase Activity	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process COP9 Signalosome Assembly Protein Modification Process Intracellular Signaling Cassette Cytosol Regulation Of Primary Metabolic Process Negative Regulation Of Mitophagy Metal-dependent Deubiquitinase Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor DNA-templated Transcription Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Stem Cell Proliferation Nucleus Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Nuclear Matrix Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Response To Glucocorticoid Cellular Response To Hypoxia Medium-term Memory Cellular Response To Prolactin Protein Metabolic Process Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Peroxisome Transport Along Microtubule