RCBTB2 and COPS4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RCBTB2	COPS4
Gene Name		regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	COP9 signalosome subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Synaptic Vesicle COP9 Signalosome Cell Junction Extracellular Vesicular Exosome
	Molecular Function	Ran Guanyl-nucleotide Exchange Factor Activity	Protein Binding
	Biological Process	Positive Regulation Of Ran GTPase Activity	Protein Deneddylation Cullin Deneddylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: COPS4 CUL3 FARS2 PDE4B UBE2E3 UBE2I	17 interactors: C19orf57 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 FOS IKBKB JUN MBIP RCBTB2 TP53 USHBP1 YWHAQ
Entrez ID		1102	51138
HPRD ID		04631	09888
Ensembl ID		ENSG00000136161	ENSG00000138663
Uniprot IDs		B4DWG0 O95199	B3KM48 Q9BT78
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SUMO Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Relaxation Of Cardiac Muscle Trophectodermal Cellular Morphogenesis Protein Polyubiquitination Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Chromosome Segregation Phenylalanyl-tRNA Aminoacylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Relaxation Of Cardiac Muscle Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Relaxation Of Muscle Cullin Deneddylation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Mitotic Nuclear Division Protein Deneddylation Embryonic Cleavage Protein Metabolic Process Neutrophil Homeostasis CAMP Catabolic Process Stress Fiber Assembly Positive Regulation Of Chromosome Segregation Cellular Protein Modification Process Cellular Response To Epinephrine Stimulus Cell Division Response To Epinephrine Cyclic Nucleotide Catabolic Process COPII Vesicle Coating Regulation Of Voltage-gated Calcium Channel Activity COPII-coated Vesicle Budding Protein K11-linked Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Purine Ribonucleotide Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Modification-dependent Protein Catabolic Process Protein Sumoylation Trophectodermal Cell Differentiation Cellular Response To Catecholamine Stimulus Mitotic Metaphase Plate Congression Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Vesicle Targeting, To, From Or Within Golgi Cellular Protein Catabolic Process Metaphase Plate Congression	Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Signal Transduction Response To Radiation Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Cellular Response To Extracellular Stimulus Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Calcium Ion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Innate Immune Response Response To Growth Factor Negative Regulation Of Nucleic Acid-templated Transcription SMAD Protein Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitochondrion Organization
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