RCBTB2 and PLA2G6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RCBTB2	PLA2G6
Name		RCC1 and BTB domain containing protein 2	phospholipase A2 group VI
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoplasmic Vesicle	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Speck Pseudopodium Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Hydrolase Activity Serine Hydrolase Activity Identical Protein Binding Calcium-independent Phospholipase A2 Activity Long-chain Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Liver Development Cell Population Proliferation Lymph Node Development Spleen Development Digestive Tract Development	Lipid Metabolic Process Chemotaxis Antibacterial Humoral Response Phosphatidylcholine Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process
Pathways		None	Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic
Drugs		None	Quinacrine
Diseases		None	Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia Parkinson's disease (PD)
GWAS		Metabolite levels ( 23823483 )	Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Body fat percentage ( 26833246 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 29059683 ) C-reactive protein levels ( 29878111 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cutaneous nevi ( 21478494 19578365 ) HDL cholesterol levels ( 32203549 ) High light scatter reticulocyte count ( 32888494 ) Mammographic density (dense area) ( 25342443 ) Melanoma ( 21983787 28212542 ) Nevus count ( 30429480 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Percent mammographic density ( 25342443 ) Platelet distribution width ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Triglyceride levels ( 32154731 28334899 32203549 ) Triglycerides ( 24097068 20686565 )
Interacting Genes		8 interacting genes: COPS4 FARS2 MORF4L1 PDE4B PLA2G6 RBBP9 TMEM132D UBE2I	11 interacting genes: CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42
Entrez ID		1102	8398
HPRD ID		04631	04675
Ensembl ID		ENSG00000136161	ENSG00000184381
Uniprot IDs		B4DWG0 B4E372 O95199 Q59FB7	O60733
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Serine Hydrolase Activity	None