KIF2C and DRD4

Data Source: HiPPIP (Novel)

		KIF2C	DRD4
Name		kinesin family member 2C	dopamine receptor D4
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end Presynapse Postsynapse Glutamatergic Synapse	Centrosome Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity Centromeric DNA Binding Microtubule Plus-end Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule-based Movement Microtubule Depolymerization Chromosome Segregation Mitotic Metaphase Chromosome Alignment Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Cytoskeleton Organization	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Adult Behavior Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonate Secretion Negative Regulation Of Protein Secretion Regulation Of Transport Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins	Dopamine receptors G alpha (i) signalling events
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester	Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Nandrolone decanoate Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		4 novel interactors: DRD4 KDM4A PMPCA TOMM70	4 novel interactors: CARS1 ETNK1 KIF2C MKI67
Interacting Genes		11 interacting genes: APP AURKA CEBPA CENPH CSNK2B H3-4 NDEL1 PLK1 SUMO2 VHL ZNF566	9 interacting genes: ADCY2 ADRB2 CLIC6 GABRA1 GNAI1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		11004	1815
HPRD ID		05172	00541
Ensembl ID		ENSG00000142945	ENSG00000069696
Uniprot IDs		A0A140VKF1 B7Z6Q6 B7Z7M6 Q99661	P21917
PDB IDs		2HEH 4UBF 4Y05 5MIO	5WIU 5WIV
GO Terms Enriched among Interactors		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Centrosome Separation Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Kinetochore Mitotic Centrosome Separation Axon Hillock Mitotic Spindle Organization Positive Regulation Of Catabolic Process Regulation Of Neurotransmitter Uptake Developmental Cell Growth Protein Heterodimerization Activity Protein Serine/threonine Kinase Binding Molecular Function Activator Activity Developmental Growth Involved In Morphogenesis Chromosome Segregation Protein Localization To Centrosome Spindle Midzone Amyloid Fibril Formation Spindle Organization Chromosome, Centromeric Region Centrosome Localization Microtubule-based Process Establishment Of Mitotic Spindle Orientation Positive Regulation Of Protein Metabolic Process Mitotic Spindle Pole Microtubule Cytoskeleton Organization Establishment Of Mitotic Spindle Localization Spindle Microtubule Peptidyl-serine Phosphorylation Establishment Of Spindle Orientation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Localization To Cytoskeleton Centrosome Cycle Histone H3K36me2/H3K36me3 Demethylase Activity	D2 Dopamine Receptor Binding Adenylate Cyclase Binding Response To Forskolin Cellular Response To Forskolin Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ephrin Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Chloride Channel Complex Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Molecular Condensate Scaffold Activity D4 Dopamine Receptor Binding Nucleotide Binding Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Biological Quality Regulation Of Organelle Organization Beta2-adrenergic Receptor Activity Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation GABA Receptor Complex Chloride Channel Activity Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Protein Polymerization Grb2-EGFR Complex Ligand-gated Monoatomic Cation Channel Activity Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Cap-dependent Translational Initiation D3 Dopamine Receptor Binding Ethanolamine Kinase Activity