AFG3L2 and RAC2

Number of citations of the paper that reports this interaction (PubMedID 31871319)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		AFG3L2	RAC2
Description		AFG3 like matrix AAA peptidase subunit 2	Rac family small GTPase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Membrane	Nuclear Envelope Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection NADPH Oxidase Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Unfolded Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Proteolysis Mitochondrion Organization Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Protein Processing Protein Autoprocessing Nerve Development Protein Catabolic Process Membrane Protein Proteolysis Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Multicellular Organism Growth Cristae Formation Myelination Mitochondrial Calcium Ion Homeostasis Protein Maturation Muscle Cell Development Righting Reflex Cellular Response To Glutathione Regulation Of Calcium Import Into The Mitochondrion Mitochondrial Protein Quality Control Glutathione Import Into Mitochondrion	Chemotaxis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Superoxide Anion Generation Erythrocyte Enucleation Regulation Of Mast Cell Degranulation Bone Resorption Respiratory Burst Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Processing of SMDT1 Mitochondrial protein degradation	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle
Drugs		ATP	Dextromethorphan
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS			Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		5 interacting genes: APP MAPK8IP2 PHC2 RAC2 RNF167	21 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 RTKN SMAD1 SMAD4
Entrez ID		10939	5880
HPRD ID		05205	03628
Ensembl ID		ENSG00000141385	ENSG00000128340
Uniprot IDs		Q8TA92 Q9Y4W6	P15153 V9H0H7
PDB IDs		2LNA 6NYY	1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		Mating Behavior Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Transmission, Glutamatergic Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Learning Lipoprotein Particle Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Chemotaxis Axon Midline Choice Point Recognition Intracellular Signaling Cassette Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Mast Cell Proliferation Mast Cell Proliferation Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Spontaneous Synaptic Transmission Regulation Of Leukocyte Migration NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway	Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Small GTPase Binding Cardiac Conduction System Development Actin Cytoskeleton Organization Cytosol Rho GDP-dissociation Inhibitor Activity Intracellular Signal Transduction Actin Filament-based Process GTPase Activator Activity Superoxide Metabolic Process SMAD Protein Complex Heteromeric SMAD Protein Complex Superoxide-generating NADPH Oxidase Activator Activity Cardiac Muscle Tissue Development Rho Protein Signal Transduction I-SMAD Binding NADPH Oxidase Complex Protein Kinase Binding Cytoplasm Reactive Oxygen Species Metabolic Process GTP-dependent Protein Binding Superoxide Anion Generation SMAD Protein Signal Transduction Negative Regulation Of Protein Catabolic Process Cortical Cytoskeleton Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Tissue Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Establishment Or Maintenance Of Cell Polarity Signal Transduction GTP Binding Muscle Tissue Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis S-adenosylmethioninamine Metabolic Process Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity
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