AFG3L2

Description		AFG3 like matrix AAA peptidase subunit 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Membrane
	Molecular Function	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process	Proteolysis Mitochondrion Organization Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Protein Processing Protein Autoprocessing Nerve Development Protein Catabolic Process Membrane Protein Proteolysis Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Multicellular Organism Growth Cristae Formation Myelination Mitochondrial Calcium Ion Homeostasis Protein Maturation Muscle Cell Development Righting Reflex Cellular Response To Glutathione Regulation Of Calcium Import Into The Mitochondrion Mitochondrial Protein Quality Control Glutathione Import Into Mitochondrion
Pathways		Processing of SMDT1 Mitochondrial protein degradation
Drugs		ATP
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Interacting Genes		5 interacting genes: APP MAPK8IP2 PHC2 RAC2 RNF167
Entrez ID		10939
HPRD ID		05205
Ensembl ID		ENSG00000141385
Uniprot IDs		Q8TA92 Q9Y4W6
PDB IDs		2LNA 6NYY
Enriched GO Terms of Interacting Partners?		Mating Behavior Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Transmission, Glutamatergic Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Learning Lipoprotein Particle Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Chemotaxis Axon Midline Choice Point Recognition Intracellular Signaling Cassette Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Mast Cell Proliferation Mast Cell Proliferation Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Spontaneous Synaptic Transmission Regulation Of Leukocyte Migration NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway
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