AFG3L2 and PHC2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AFG3L2	PHC2
Gene Name		AFG3-like AAA ATPase 2	polyhomeotic homolog 2 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding Unfolded Protein Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Proteolysis Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Death Nerve Development Mitochondrial Protein Processing Regulation Of Multicellular Organism Growth Cristae Formation Myelination Muscle Fiber Development Righting Reflex	Multicellular Organismal Development Spermatogenesis
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP MAPK8IP2 PHC2 RAC2	68 interactors: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX8 CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 GFI1B GRB2 HIST3H3 KAT5 KBTBD7 KDM1A KIFC3 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLK1 POLR2L PPP1R16B PRKAA1 PRPF31 RBM39 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 ZBTB24 ZGPAT ZMAT2 ZNF417
Entrez ID		10939	1912
HPRD ID		05205	10340
Ensembl ID		ENSG00000141385	ENSG00000134686
Uniprot IDs		Q8TA92 Q9Y4W6	B3KPJ4 Q8IXK0
PDB IDs		2LNA
Enriched GO Terms of Interacting Partners?		Mating Behavior Mating Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Sexual Reproduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Learning Dendrite Development Neuron Development Synaptic Growth At Neuromuscular Junction Reproduction Cell Morphogenesis Platelet Activation Neuron Differentiation Cell Projection Organization Collateral Sprouting In Absence Of Injury Reproductive Process Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Nonassociative Learning Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Generation Of Neurons Neurogenesis Neuron Remodeling Axon Guidance Regulation Of Hydrogen Peroxide Metabolic Process Multicellular Organismal Development Cell Development Blood Coagulation Hemostasis Regulation Of Respiratory Burst Cellular Component Assembly Single-organism Behavior Positive Regulation Of Lamellipodium Assembly Signal Complex Assembly Positive Regulation Of Lamellipodium Organization Axonogenesis Developmental Process Cellular Copper Ion Homeostasis Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Axon Development Nervous System Development Regulation Of Body Fluid Levels	RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Chromatin Organization Chromosome Organization Chromatin Modification Organelle Organization Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Phosphorylation Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Histone Modification Cellular Response To DNA Damage Stimulus Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Developmental Process Positive Regulation Of Signal Transduction Immune System Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Anatomical Structure Development Response To Ionizing Radiation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Immune System Development Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction
Tagcloud ?		acetylcysteine anterograde antioxidants ataxia axonal axons consistently cytoskeletal deficiencies deleted depleted dynamin fragmentation gtpase hyperphosphorylation impair inner mitochondrial neurodegeneration neurons observe oma1 opa1 postnatally restored sca28 spinocerebellar transport	ansa arene bent binuclear bp86 c6 cf3 chelate concurred conversions coordinative diphenylethane ga gaga gallium h5 hexamethylbenzene me2 me3 me6 mesitylene multinuclear olefinic ph2 polyisobutylene reactivities terphenyl univalent xylene
Tagcloud (Difference) ?		acetylcysteine anterograde antioxidants ataxia axonal axons consistently cytoskeletal deficiencies deleted depleted dynamin fragmentation gtpase hyperphosphorylation impair inner mitochondrial neurodegeneration neurons observe oma1 opa1 postnatally restored sca28 spinocerebellar transport	ansa arene bent binuclear bp86 c6 cf3 chelate concurred conversions coordinative diphenylethane ga gaga gallium h5 hexamethylbenzene me2 me3 me6 mesitylene multinuclear olefinic ph2 polyisobutylene reactivities terphenyl univalent xylene
Tagcloud (Intersection) ?