AFG3L2 and PHC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AFG3L2	PHC2
Description		AFG3 like matrix AAA peptidase subunit 2	polyhomeotic homolog 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Membrane	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Unfolded Protein Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Mitochondrion Organization Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Protein Processing Protein Autoprocessing Nerve Development Protein Catabolic Process Membrane Protein Proteolysis Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Multicellular Organism Growth Cristae Formation Myelination Mitochondrial Calcium Ion Homeostasis Protein Maturation Muscle Cell Development Righting Reflex Cellular Response To Glutathione Regulation Of Calcium Import Into The Mitochondrion Mitochondrial Protein Quality Control Glutathione Import Into Mitochondrion	Spermatogenesis Negative Regulation Of DNA-templated Transcription
Pathways		Processing of SMDT1 Mitochondrial protein degradation	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs		ATP
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Blood urea nitrogen levels ( 29403010 31152163) General risk tolerance (MTAG) ( 30643258) Pancreas volume ( 34128465) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		5 interacting genes: APP MAPK8IP2 PHC2 RAC2 RNF167	78 interacting genes: AEN AFG3L2 AIRIM AP1M1 BMI1 BSDC1 BYSL CARD9 CRK CRKL DNMT1 DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB FXR1 FXR2 GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF3 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417
Entrez ID		10939	1912
HPRD ID		05205	10340
Ensembl ID		ENSG00000141385	ENSG00000134686
Uniprot IDs		Q8TA92 Q9Y4W6	A0A0A0MSI2 A0A994J5J9 Q8IXK0
PDB IDs		2LNA 6NYY
Enriched GO Terms of Interacting Partners?		Mating Behavior Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Transmission, Glutamatergic Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Learning Lipoprotein Particle Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Chemotaxis Axon Midline Choice Point Recognition Intracellular Signaling Cassette Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Mast Cell Proliferation Mast Cell Proliferation Erythrocyte Enucleation Lymphocyte Aggregation Regulation Of Spontaneous Synaptic Transmission Regulation Of Leukocyte Migration NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway	Nucleus Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process PRC1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Negative Regulation Of Metabolic Process Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Diapedesis Negative Regulation Of Biosynthetic Process PcG Protein Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Chromatin Remodeling Identical Protein Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Rac Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Helper T Cell Diapedesis DNA-binding Transcription Factor Binding Response To Ionizing Radiation RING-like Zinc Finger Domain Binding Cerebellar Neuron Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Protein Localization To Nucleus U2-type Precatalytic Spliceosome Heterochromatin Response To Muramyl Dipeptide Regulation Of Macromolecule Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Histone Binding Metal Ion Binding Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Ephrin Receptor Binding Promoter-specific Chromatin Binding MLL1 Complex
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