BRD8 and IL3

		BRD8	IL3
Description		bromodomain containing 8	interleukin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Swr1 Complex Nucleus Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex	Extracellular Region Extracellular Space
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Thyroid Hormone Receptor Binding	Cytokine Activity Interleukin-3 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Chromatin Organization Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT
Pathways		HATs acetylate histones	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling
Drugs			Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)	Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		13 interacting genes: AGTR1 EP400 EP400P1 FSD2 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1	7 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD S100A6 S100P
Entrez ID		10902	3562
HPRD ID		04166	00987
Ensembl ID		ENSG00000112983	ENSG00000164399
Uniprot IDs		B4DEG9 B4DMS9 B4DN43 Q9H0E9	P08700
PDB IDs			1JLI 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?		Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process NuA4 Histone Acetyltransferase Complex DNA Binding Domain Binding Positive Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Receptor Activity Positive Regulation Of Metabolic Process LBD Domain Binding MRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Swr1 Complex Regulation Of DNA Repair Positive Regulation Of DNA Recombination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Monocyte Differentiation Nucleosome Regulation Of Cell Cycle RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Regulation Of Lipid Transport Regulation Of DNA Recombination Negative Regulation Of SMAD Protein Signal Transduction Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Double-strand Break Repair Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Macrophage Derived Foam Cell Differentiation Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Chromatin Organization Transcription Coregulator Binding Regulation Of Cholesterol Efflux	Interleukin-3 Receptor Activity Regulation Of Cell Population Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol 3-kinase Complex Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Signal Transduction T Cell Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune System Process Regulation Of Cytoskeleton Organization Cytokine Receptor Activity Adipose Tissue Development Regulation Of Cell Cycle Regulation Of Erythrocyte Differentiation Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Fibroblast Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein Folding Chaperone Immune System Process Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Microtubule Polymerization Adaptive Immune Response Perinuclear Region Of Cytoplasm Connective Tissue Development Interleukin-5 Receptor Activity Insulin Receptor Signaling Pathway GTPase Complex Denatured Protein Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
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