YIF1A and PRIM1

		YIF1A	PRIM1
Description		Yip1 interacting factor homolog A, membrane trafficking protein	DNA primase subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	DNA-directed RNA Polymerase Complex Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane
	Molecular Function	Protein Binding	Magnesium Ion Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleotide Binding Metal Ion Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation
Pathways		XBP1(S) activates chaperone genes	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Glucose homeostasis traits ( 25524916)	Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 29403010)
Interacting Genes		71 interacting genes: APOA5 AQP6 ARLN BNIP2 CD79A CDK2AP2 CERS2 CNRIP1 CST6 EBP ELOVL4 ERGIC3 FAM210B FARS2 FCER1G FFAR2 GAS7 GJA8 GPR37 GPR42 GPX8 JOSD2 LNPK LSS MARCHF5 MGST3 MIEF2 MLLT1 MMGT1 MSMO1 MTERF3 MYG1 NDRG4 PLEKHF2 PPIF PTGES PTPN9 RBFA REEP2 REEP4 RIC3 RNF144A SCN3B SCN4B SDCBP SEC23IP SLC10A1 SLC34A1 SLC35H1 SNX10 SNX11 SNX2 SYTL2 SYTL5 TIMMDC1 TMEM139 TMEM14B TMEM17 TMEM225B TMEM248 TMEM31 TMX2 VKORC1 VMA21 WDFY2 YIPF4 YIPF5 ZDHHC16 ZDHHC17 ZFYVE21 ZFYVE27	5 interacting genes: MDC1 MRPL38 OGT PRIM2 TP53
Entrez ID		10897	5557
HPRD ID		06755	08899
Ensembl ID		ENSG00000174851	ENSG00000198056
Uniprot IDs		A6NGW1 A8K509 O95070	P49642
PDB IDs			4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Protein Binding Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Glutathione Peroxidase Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Regulation Of Mast Cell Apoptotic Process Endoplasmic Reticulum Organization	Nucleoplasm DNA-binding Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Nickel Cation Transmembrane Transporter Activity Nickel Cation Transport Nickel Cation Transmembrane Transport Solute:proton Symporter Activity Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity Macromolecule Biosynthetic Process Growth Plate Cartilage Chondrocyte Growth Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation Positive Regulation Of DNA Recombination Isotype Switching To IgE Isotypes Transcription Coactivator Binding Mammary Gland Morphogenesis T Cell Lineage Commitment Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Helicase Activity Regulation Of Carbohydrate Catabolic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Proteolysis Germ Cell Nucleus Cellular Response To Actinomycin D Mitophagy
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