PRIM1

Gene Name		primase, DNA, polypeptide 1 (49kDa)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Membrane Primosome Complex
	Molecular Function	DNA Primase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201)
Protein-protein Interactions		3 interactors: MDC1 MRPL38 TP53
Entrez ID		5557
HPRD ID		08899
Ensembl ID		ENSG00000198056
Uniprot IDs		P49642
PDB IDs		4BPU 4BPW 4BPX
Enriched GO Terms of Interacting Partners?		Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Double-strand Break Repair DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Negative Regulation Of Helicase Activity Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Mitochondrial DNA Repair Mitochondrion Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Cell Cycle ER Overload Response Intra-S DNA Damage Checkpoint Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process DNA Repair Regulation Of Thymocyte Apoptotic Process Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Rhythmic Behavior Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Protein Oligomerization Mitotic Cell Cycle Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process RRNA Transcription T Cell Lineage Commitment Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod
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