PRIM1 and PRIM2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, biochemical, cross-linking study)

		PRIM1	PRIM2
Description		DNA primase subunit 1	DNA primase subunit 2
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex
	Molecular Function	Magnesium Ion Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleotide Binding Metal Ion Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding DNA/RNA Hybrid Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 29403010)	Chronotype ( 30696823) Coronary artery disease ( 33020668) Daytime nap ( 33568662) Myocardial infarction ( 33532862) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)
Interacting Genes		5 interacting genes: MDC1 MRPL38 OGT PRIM2 TP53	7 interacting genes: KDM1A OGT POLA1 POLA2 PRIM1 RECK SUV39H1
Entrez ID		5557	5558
HPRD ID		08899	08900
Ensembl ID		ENSG00000198056	ENSG00000146143
Uniprot IDs		P49642	P49643
PDB IDs		4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V	3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Nucleoplasm DNA-binding Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Nickel Cation Transmembrane Transporter Activity Nickel Cation Transport Nickel Cation Transmembrane Transport Solute:proton Symporter Activity Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity Macromolecule Biosynthetic Process Growth Plate Cartilage Chondrocyte Growth Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation Positive Regulation Of DNA Recombination Isotype Switching To IgE Isotypes Transcription Coactivator Binding Mammary Gland Morphogenesis T Cell Lineage Commitment Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Helicase Activity Regulation Of Carbohydrate Catabolic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Proteolysis Germ Cell Nucleus Cellular Response To Actinomycin D Mitophagy	Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication Initiation Regulation Of Transcription By Glucose Macromolecule Biosynthetic Process Nucleoplasm DNA Replication Chromatin Binding Embryonic Forelimb Morphogenesis Developmental Maturation Forelimb Morphogenesis Macromolecule Metabolic Process Positive Regulation Of Stem Cell Proliferation RNA Metabolic Process Ligamentous Ossification Ribonucleotide Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromatin DNA Binding Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Nucleotidyltransferase Activity Limb Morphogenesis Regulation Of Multicellular Organismal Process Osteoblast Fate Commitment Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair ENoSc Complex Regulation Of Establishment Of Blood-brain Barrier Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Ossification Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Leading Strand Elongation Histone H3K9 Trimethyltransferase Activity Circadian Rhythm Protein Demethylase Activity RDNA Heterochromatin Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Cold-induced Thermogenesis Regulation Of Transcription From RNA Polymerase II Promoter By Glucose MRF Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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