HCST and SPOP

Number of citations of the paper that reports this interaction (PMID 10426994)
135

Data Source:
HPRD (in vivo, in vitro)

		HCST	SPOP
Gene Name		hematopoietic cell signal transducer	speckle-type POZ protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Nucleus Nucleoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	RNA Polymerase II Transcription Factor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Immune Response	Glucose Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Hedgehog 'on' state Signaling by Hedgehog
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: KLRK1 PIK3R1 SPOP	19 interactors: AR BRMS1 DAXX DDIT3 DPPA2 FADD GIT2 H2AFY HCST MYD88 PDX1 PIAS1 RTN3 RXRB SRRM1 TRAF1 TRAF6 UBE2E3 ZBTB16
Entrez ID		10870	8405
HPRD ID		04971	16004
Ensembl ID		ENSG00000126264	ENSG00000121067
Uniprot IDs		Q9UBK5	O43791
PDB IDs			2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z
Enriched GO Terms of Interacting Partners?		T Cell Costimulation NFAT Protein Import Into Nucleus Glucose Homeostasis Positive Regulation Of T Cell Activation Transcription Factor Import Into Nucleus Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Lymphocyte Activation Regulation Of Cell Activation Leukocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Activation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Phosphatidylinositol 3-kinase Signaling Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Natural Killer Cell Mediated Immunity Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Growth Hormone Stimulus Innate Immune Response Negative Regulation Of Osteoclast Differentiation Chemical Homeostasis Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of RNA Splicing Negative Regulation Of Cell-matrix Adhesion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Transcription Factor Import Into Nucleus Response To Growth Hormone Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Glucose Import Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Glucose Transport Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Intracellular Receptor Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Transcription, DNA-templated Androgen Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Transcription From RNA Polymerase II Promoter JNK Cascade RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Activation
Tagcloud ?		1p36 bac bears border centromeric consists cort cortistatin d1s244 defines exonic exons ganglioneuromas intron kb mapping neuroblastoma neuroblastomas overlap p36 polymorphic preprocortistatin processed resemblance smallest somatostatin sst sstr	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		1p36 bac bears border centromeric consists cort cortistatin d1s244 defines exonic exons ganglioneuromas intron kb mapping neuroblastoma neuroblastomas overlap p36 polymorphic preprocortistatin processed resemblance smallest somatostatin sst sstr	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?