RUVBL2 and PIH1D1

Number of citations of the paper that reports this interaction (PMID 17636026)
22

Data Source:
BioGRID (pull down)

		RUVBL2	PIH1D1
Gene Name		RuvB-like AAA ATPase 2	PIH1 domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Swr1 Complex Intracellular Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Membrane Nuclear Matrix Ribonucleoprotein Complex Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Vesicular Exosome MLL1 Complex	Pre-snoRNP Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Helicase Activity Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding ATPase Activity Chromatin DNA Binding Identical Protein Binding ATP-dependent 5'-3' DNA Helicase Activity Unfolded Protein Binding	Protein Binding
	Biological Process	DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Protein Folding DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding	Box C/D SnoRNP Assembly Epithelial Cell Differentiation
Pathways		Chromatin modifying enzymes Telomere Maintenance Chromosome Maintenance Chromatin organization Extension of Telomeres Telomere Extension By Telomerase HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DPCD EHMT2 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MDM2 NDRG1 NUFIP1 PIH1D1 RUVBL1 STOM TAF9 TBP TERT YWHAQ	7 interactors: CA4 FBL MAPK6 RBPMS RUVBL1 RUVBL2 TSC22D4
Entrez ID		10856	55011
HPRD ID		16070	07938
Ensembl ID		ENSG00000183207	ENSG00000104872
Uniprot IDs		B3KNL2 B3KQ59 Q9Y230	Q9NWS0
PDB IDs		2CQA 2XSZ 3UK6
Enriched GO Terms of Interacting Partners?		Chromatin Modification Positive Regulation Of Gene Expression Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Component Assembly Peptidyl-lysine Modification Apoptotic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Cell Death Death Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Death Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone H3-K9 Modification Developmental Process Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Sexual Reproduction Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Response To DNA Damage Stimulus Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Fungiform Papilla Formation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Chromatin Remodeling	Histone H2A Acetylation Histone H4 Acetylation Histone Modification DNA Duplex Unwinding DNA Geometric Change Histone Glutamine Methylation Histone Acetylation Internal Peptidyl-lysine Acetylation Chromatin Modification Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Peptidyl-glutamine Methylation Protein Acetylation RNA Metabolic Process Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Chromatin Organization SnoRNA Metabolic Process Chromatin Remodeling Establishment Of Protein Localization To Chromatin DNA Recombination Negative Regulation Of Receptor Binding Peptidyl-lysine Modification Chromosome Organization Transcription, DNA-templated DNA Conformation Change Cellular Metabolic Process RNA Biosynthetic Process Protein Localization To Chromatin Nucleobase-containing Compound Metabolic Process Positive Regulation Of SMAD Protein Import Into Nucleus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Estradiol Stimulus Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Histone Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Response To Steroid Hormone CENP-A Containing Nucleosome Assembly Cellular Protein Modification Process Cellular Response To Estrogen Stimulus Protein Localization To Chromosome Nitrogen Compound Metabolic Process Bicarbonate Transport Histone Exchange DNA Replication-independent Nucleosome Assembly Gene Expression DNA Repair
Tagcloud ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	atpases biochemistry chaperone ck2 client cochaperones connection connects consisting depends hsp90 mediates metazoa pi3 polymerases r2tp rpap3 rvb1 rvb2 simultaneously snornps spagh structural tah1 tel2 tti1 tti2 ttt
Tagcloud (Difference) ?		ac accessible architecture attenuates baz1b clarify cytoprotective foci gammah2ax h2ax h3k56 h3k9 hubs integrated ints3 irradiation isoform mark matrix mount prevents proteomic respond runx runx2 scaffolding subnuclear supported	atpases biochemistry chaperone ck2 client cochaperones connection connects consisting depends hsp90 mediates metazoa pi3 polymerases r2tp rpap3 rvb1 rvb2 simultaneously snornps spagh structural tah1 tel2 tti1 tti2 ttt
Tagcloud (Intersection) ?