NOXA1 and NADSYN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NOXA1	NADSYN1
Description		NADPH oxidase activator 1	NAD synthetase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane NADPH Oxidase Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding Identical Protein Binding	Nucleotide Binding NAD+ Synthase (glutamine-hydrolyzing) Activity Glutaminase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Respiratory Burst	NAD+ Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan NAD+ Biosynthetic Process Via The Salvage Pathway
Pathways		RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	Nicotinate metabolism
Drugs			Glutamic acid
Diseases
GWAS		Response to fenofibrate (total cholesterol levels) ( 27002377)	Systemic lupus erythematosus ( 26502338) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 20418485 29343764) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764)
Interacting Genes		57 interacting genes: ACTMAP ANKRD55 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 SPMIP6 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620	13 interacting genes: ANKS1A COL8A1 CREB5 CUTC FRS3 GPANK1 HGS HOXC8 MYO15B NOXA1 NTAQ1 TFG UPF1
Entrez ID		10811	55191
HPRD ID		17644	16309
Ensembl ID		ENSG00000188747	ENSG00000172890
Uniprot IDs		Q86UR1	Q6IA69
PDB IDs		7CFZ	6OFB
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Regulation Of Respiratory Burst Respiratory Burst Regulation Of Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Manchette Benzodiazepine Receptor Binding Erythrocyte Enucleation Protein Binding Intermediate Filament Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Cytokine Production Superoxide-generating NADPH Oxidase Activator Activity Intracellular Signaling Cassette Internal Protein Amino Acid Acetylation Negative Regulation Of Glial Cell Apoptotic Process Thioesterase Binding
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