NOXA1 and DCLRE1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NOXA1	DCLRE1B
Description		NADPH oxidase activator 1	DNA cross-link repair 1B
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane NADPH Oxidase Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Nuclear Body
	Molecular Function	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding Identical Protein Binding	Damaged DNA Binding Nuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Beta-lactamase Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Respiratory Burst	Telomere Maintenance DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Interstrand Cross-link Repair
Pathways		RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Response to fenofibrate (total cholesterol levels) ( 27002377)	Alopecia areata ( 25608926) Breast cancer ( 23535729 29059683) Coronary artery disease ( 33020668) Crohn's disease ( 23128233 28067908) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		57 interacting genes: ACTMAP ANKRD55 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 SPMIP6 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620	4 interacting genes: NOXA1 SPAG5 TFR2 TRIM54
Entrez ID		10811	64858
HPRD ID		17644	16785
Ensembl ID		ENSG00000188747	ENSG00000118655
Uniprot IDs		Q86UR1	Q9H816
PDB IDs		7CFZ	3BUA 5AHO 7A1F 7B2X 7B9B
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Regulation Of Respiratory Burst Respiratory Burst Regulation Of Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Manchette Benzodiazepine Receptor Binding Erythrocyte Enucleation Protein Binding Intermediate Filament Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Cytokine Production Superoxide-generating NADPH Oxidase Activator Activity Intracellular Signaling Cassette Internal Protein Amino Acid Acetylation Negative Regulation Of Glial Cell Apoptotic Process Thioesterase Binding	Transferrin Receptor Activity Endocytic Iron Import Into Cell Regulation Of Microtubule Cytoskeleton Organization HFE-transferrin Receptor Complex Cellular Response To Iron Ion Iron Import Into Cell Regulation Of Microtubule-based Process Positive Regulation Of Spindle Assembly Ciliary Rootlet Microtubule Binding Superoxide-generating NADPH Oxidase Activator Activity Microtubule Transferrin Transport Co-receptor Binding Regulation Of Metaphase Plate Congression
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