WASF3 and PIK3R2

Number of citations of the paper that reports this interaction (PubMedID 15826941)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		WASF3	PIK3R2
Description		WASP family member 3	phosphoinositide-3-kinase regulatory subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome Glial Cell Projection Postsynapse Glutamatergic Synapse	Nucleus Cytosol Focal Adhesion Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Actin Binding Protein Binding Protein Kinase A Regulatory Subunit Binding Arp2/3 Complex Binding	Phosphotyrosine Residue Binding GTPase Activator Activity Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Oligodendrocyte Development Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Myelination Protein-containing Complex Assembly Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Intracellular Glucose Homeostasis Immune Response Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Autophagy Protein Transport B Cell Differentiation T Cell Differentiation Regulation Of Actin Filament Polymerization Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Regulation Of Protein Localization To Plasma Membrane
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs			SF1126
Diseases
GWAS		Hallux valgus ( 32131869) Left-handedness ( 32989287) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Sporadic pituitary adenoma ( 26029870) Systolic blood pressure ( 30224653)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887)
Interacting Genes		12 interacting genes: ABI2 ACTB ACTR3 BYSL CAMK2D CKS1B EGFR KANK2 KIFC3 PIK3R1 PIK3R2 RASAL3	60 interacting genes: APP APPL1 AR ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GAB1 GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MET MRFAP1L1 PDGFRB PIK3CB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		10810	5296
HPRD ID		05458	04404
Ensembl ID		ENSG00000132970	ENSG00000105647
Uniprot IDs		Q5T8P4 Q9UPY6	O00459
PDB IDs			2KT1 2XS6 3MTT 3O5Z 6OX7 6U28 7RCH 7RNU
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Membrane Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Adherens Junction Organization Regulation Of Lamellipodium Organization 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Motility Protein Phosphatase Binding Adherens Junction Assembly Regulation Of Cellular Component Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Protein Localization To Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Intracellular Signaling Cassette Cell-cell Junction Organization Regulation Of Cell Cycle G1/S Phase Transition Adherens Junction Lamellipodium Regulation Of Mitotic Cell Cycle Cell-cell Junction Positive Regulation Of Protein Import Into Nucleus Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Phosphotyrosine Residue Binding Regulation Of Cell Projection Assembly Positive Regulation Of Norepinephrine Uptake Identical Protein Binding Cellular Response To Cytochalasin B Multivesicular Body, Internal Vesicle Lumen GTPase Activator Activity Brush Border Regulation Of Protein Import Into Nucleus Regulation Of Organelle Organization Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Norepinephrine Uptake Positive Regulation Of Protein Localization To Cell Periphery	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Receptor Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Locomotion Kinase Activity Positive Regulation Of MAPK Cascade Protein Kinase Activity Developmental Process Peptidyl-tyrosine Phosphorylation Response To Growth Factor Positive Regulation Of Multicellular Organismal Process Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development Cell Population Proliferation Growth Factor Binding Positive Regulation Of Epithelial Cell Proliferation Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Morphogenesis Of An Epithelium ERBB Signaling Pathway Tissue Morphogenesis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?