WASF3

Description		WASP family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome Glial Cell Projection Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Protein Kinase A Regulatory Subunit Binding Arp2/3 Complex Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Oligodendrocyte Development Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Myelination Protein-containing Complex Assembly Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Hallux valgus ( 32131869) Left-handedness ( 32989287) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Sporadic pituitary adenoma ( 26029870) Systolic blood pressure ( 30224653)
Interacting Genes		12 interacting genes: ABI2 ACTB ACTR3 BYSL CAMK2D CKS1B EGFR KANK2 KIFC3 PIK3R1 PIK3R2 RASAL3
Entrez ID		10810
HPRD ID		05458
Ensembl ID		ENSG00000132970
Uniprot IDs		Q5T8P4 Q9UPY6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Membrane Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Adherens Junction Organization Regulation Of Lamellipodium Organization 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cellular Localization Regulation Of Protein Localization Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Motility Protein Phosphatase Binding Adherens Junction Assembly Regulation Of Cellular Component Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Protein Localization To Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Intracellular Signaling Cassette Cell-cell Junction Organization Regulation Of Cell Cycle G1/S Phase Transition Adherens Junction Lamellipodium Regulation Of Mitotic Cell Cycle Cell-cell Junction Positive Regulation Of Protein Import Into Nucleus Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Phosphotyrosine Residue Binding Regulation Of Cell Projection Assembly Positive Regulation Of Norepinephrine Uptake Identical Protein Binding Cellular Response To Cytochalasin B Multivesicular Body, Internal Vesicle Lumen GTPase Activator Activity Brush Border Regulation Of Protein Import Into Nucleus Regulation Of Organelle Organization Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Norepinephrine Uptake Positive Regulation Of Protein Localization To Cell Periphery
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