CAPZA2 and CAPZA3

Number of citations of the paper that reports this interaction (PubMedID 12029070)
0

Data Source:
HPRD (in vitro)

		CAPZA2	CAPZA3
Description		capping actin protein of muscle Z-line subunit alpha 2	capping actin protein of muscle Z-line subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Brush Border F-actin Capping Protein Complex Actin Cytoskeleton Membrane Cortical Cytoskeleton Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton F-actin Capping Protein Complex Membrane Cortical Cytoskeleton Sperm Head
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Actin Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly	Actin Filament Organization Cytoplasm Organization Spermatid Development Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Filament Capping
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878) Triglyceride levels ( 32154731 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Daytime sleep phenotypes ( 27126917) Personality dimensions ( 23903073)
Interacting Genes		5 interacting genes: CAPZA3 HSPB2 PDE4B RBBP6 WDR4	2 interacting genes: ACTG1 CAPZA2
Entrez ID		830	93661
HPRD ID		11871	12282
Ensembl ID		ENSG00000198898	ENSG00000177938
Uniprot IDs		A4D0V4 P47755	A0A140VKF6 Q96KX2
PDB IDs
Enriched GO Terms of Interacting Partners?		Somatic Muscle Development Protein Folding Cytosol Enzyme Activator Activity Neutrophil Homeostasis Negative Regulation Of Relaxation Of Muscle CAMP Catabolic Process Postsynaptic Density Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Actin Filament-based Process Regulation Of Relaxation Of Cardiac Muscle Memory T Cell Differentiation Regulation Of Cellular Component Size TSC1-TSC2 Complex ATPase Inhibitor Activity Negative Regulation Of Cell Size TRNA Methyltransferase Complex RNA (guanine-N7)-methylation TRNA (guanine-N7)-methylation TRNA Stabilization TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex F-actin Capping Protein Complex Cytoplasm Organization	Protein Localization To Bicellular Tight Junction Actin Filament-based Process Basal Body Patch Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Transepithelial Transport Actin Cytoskeleton Organization Actin Cytoskeleton Dense Body Regulation Of Supramolecular Fiber Organization Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Cytoskeleton Organization F-actin Capping Protein Complex Profilin Binding Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Barbed-end Actin Filament Capping Postsynaptic Cytoskeleton Organization Filamentous Actin Apical Junction Complex NuA4 Histone Acetyltransferase Complex Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Cortical Cytoskeleton Maintenance Of Blood-brain Barrier Actin Filament Capping Regulation Of Organelle Organization Sarcomere Organization Negative Regulation Of Actin Filament Depolymerization Myofibril Platelet Aggregation Negative Regulation Of Actin Filament Polymerization Tight Junction Assembly Regulation Of Actin Filament Depolymerization Tight Junction Organization Brush Border Homotypic Cell-cell Adhesion Positive Regulation Of Wound Healing Regulation Of Focal Adhesion Assembly Cellular Response To Type II Interferon Regulation Of Cell-substrate Junction Organization Negative Regulation Of Protein-containing Complex Disassembly Protein Localization To Cell Junction Apical Part Of Cell Actin Filament Phagocytic Vesicle
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