CAPZA2

Name	capping actin protein of muscle Z-line subunit alpha 2
Structure	No pdb structure
Novel Interactors	1 novel interactors: TSC1
Interactors	5 interactors: CAPZA3 HSPB2 PDE4B RBBP6 WDR4
GO Annotations	Cellular Component	Extracellular Region Cytosol Brush Border F-actin Capping Protein Complex Actin Cytoskeleton Membrane Cortical Cytoskeleton Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly
Pathways	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
GWAS	Heel bone mineral density x serum urate levels interaction ( 34046847 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Pulse pressure ( 27841878 ) Triglyceride levels ( 32154731 32203549 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Entrez ID	830
HPRD ID	11871
Ensembl ID	ENSG00000198898
Uniprot IDs	A4D0V4 P47755
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Somatic Muscle Development Protein Folding Cytosol Enzyme Activator Activity Neutrophil Homeostasis Negative Regulation Of Relaxation Of Muscle CAMP Catabolic Process Postsynaptic Density Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Actin Filament-based Process Regulation Of Relaxation Of Cardiac Muscle Memory T Cell Differentiation Regulation Of Cellular Component Size TSC1-TSC2 Complex ATPase Inhibitor Activity Negative Regulation Of Cell Size TRNA Methyltransferase Complex RNA (guanine-N7)-methylation TRNA (guanine-N7)-methylation TRNA Stabilization TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex F-actin Capping Protein Complex Cytoplasm Organization