CAPZA2

Description		capping actin protein of muscle Z-line subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Brush Border F-actin Capping Protein Complex Actin Cytoskeleton Membrane Cortical Cytoskeleton Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878) Triglyceride levels ( 32154731 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: TSC1
Interacting Genes		5 interacting genes: CAPZA3 HSPB2 PDE4B RBBP6 WDR4
Entrez ID		830
HPRD ID		11871
Ensembl ID		ENSG00000198898
Uniprot IDs		A4D0V4 P47755
PDB IDs
Enriched GO Terms of Interacting Partners?		Somatic Muscle Development Protein Folding Cytosol Enzyme Activator Activity Neutrophil Homeostasis Negative Regulation Of Relaxation Of Muscle CAMP Catabolic Process Postsynaptic Density Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Relaxation Of Cardiac Muscle Regulation Of Actin Filament-based Process Regulation Of Relaxation Of Cardiac Muscle Memory T Cell Differentiation Regulation Of Cellular Component Size TSC1-TSC2 Complex ATPase Inhibitor Activity Negative Regulation Of Cell Size TRNA Methyltransferase Complex RNA (guanine-N7)-methylation TRNA (guanine-N7)-methylation TRNA Stabilization TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex F-actin Capping Protein Complex Cytoplasm Organization
Tagcloud ?