ZNF587 and ZKSCAN8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF587	ZKSCAN8
Description		zinc finger protein 587	zinc finger with KRAB and SCAN domains 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Generic Transcription Pathway	Generic Transcription Pathway
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)	Alanine aminotransferase levels ( 33547301) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean corpuscular volume ( 27863252) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		130 interacting genes: ADAMTSL4 AQP6 ASB15 ASB6 AXIN2 BEGAIN C17orf50 CARD10 CARD9 CCDC125 CCDC136 CCDC85B CEP44 CEP70 CHRDL2 CSRNP1 CYSRT1 DEF8 DHX57 EFEMP2 FCHSD2 FHL3 FHL5 FSD2 FST GOLGA2 GOLGA6L9 GOPC GSC2 HMBOX1 HOOK2 HOXA1 HSF2BP IGFBP6 IKBKG IKZF1 IKZF3 INSC ISY1-RAB43 KATNBL1 KCTD7 KPRP KRT31 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-7 KRTAP5-9 LDOC1 LHX3 LIMS1 LMO3 LRP2BP LZTS1 MCCD1 MDFI MEOX2 MID2 MKRN3 MTUS2 MYF5 NBPF19 NDUFB7 NEK6 NKAPL NOTCH2NLA NR1D2 PBX2 PDE4DIP PLSCR1 PNMA2 PPARA PRDM14 PRICKLE4 PRPF31 RORB RUNDC3A SMAD9 SMYD5 SOX13 SPRED1 SPRY2 SPRY3 SSX2IP STX11 TBC1D26 TCF4 TENM4 TFIP11 TMCC2 TNS2 TRAF1 TRIB3 TRIM23 TRIM27 TRIM36 TRIM37 TRIM41 TRIM54 TSC1 TSGA10 TXK VPS52 VWC2 ZBTB43 ZBTB8A ZGPAT ZIM2 ZKSCAN8 ZNF286A ZNF330 ZNF417 ZNF547 ZNF774 ZNF829 ZNF837 ZRANB1	10 interacting genes: APP FBXO7 MAGOH OGT PRNP TCEA2 ZNF165 ZNF174 ZNF24 ZNF587
Entrez ID		84914	7745
HPRD ID		15864	03760
Ensembl ID		ENSG00000198466	ENSG00000198315
Uniprot IDs		Q96SQ5	Q15776 Q59HG5
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Zinc Ion Binding Protein Binding Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cellular Response To Copper Ion Regulation Of Primary Metabolic Process Molecular Function Activator Activity Response To Copper Ion Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Neuron Apoptotic Process DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Amyloid-beta Type 8 Metabotropic Glutamate Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Synapse Organization Regulation Of Carbohydrate Catabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Autophagy Of Mitochondrion Regulation Of ATP Metabolic Process Nucleus
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