SRSF10 and TRA2A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		SRSF10	TRA2A
Description		serine and arginine rich splicing factor 10	transformer 2 alpha homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Dendrite Neuronal Cell Body Axon Terminus	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RS Domain Binding Unfolded Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription MRNA Splice Site Recognition MRNA Processing RNA Splicing Cytosolic Transport Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Chronotype ( 30696823) Obesity-related traits ( 23251661)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		24 interacting genes: CLK1 CLK2 CLK3 CLK4 CSNK2A1 DAPK1 DYRK1A EXOSC8 FBXO7 FUS H19 MPP1 PTPN11 SNRNP70 SREK1 SRPK1 SRSF1 SRSF4 SUN2 SYCE1L TRA2A TRA2B YWHAB YWHAG	82 interacting genes: C11orf58 CDK2AP2 CDK6 CRABP1 DHX15 FOXP1 LBP MAGOHB MIR1-1 MIR1-2 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR199A1 MIR199A2 MIR19A MIR19B1 MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NUDT21 NXF1 PPP1CC RNPS1 SELENBP1 SRSF10 TNNT1 U2SURP UBE4B XPOT YTHDC1 YWHAG
Entrez ID		10772	29896
HPRD ID		05562	04096
Ensembl ID		ENSG00000188529	ENSG00000164548
Uniprot IDs		A0A0S2Z504 B3KNY6 O75494 Q5JRI1	Q13595 Q549U1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Protein Serine/threonine/tyrosine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity RNA Splicing Protein Serine/threonine Kinase Activity MRNA Metabolic Process Nuclear Speck Protein Kinase Activity Nucleus Protein Tyrosine Kinase Activity Kinase Activity RNA Processing Regulation Of Gene Expression MRNA Processing RNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Spliceosomal Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Identical Protein Binding Nucleic Acid Binding RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Phosphorylation Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Protein Targeting Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Binding ATP Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Autophosphorylation Negative Regulation Of RNA Splicing Negative Regulation Of Gene Expression Regulation Of Response To Tumor Cell Positive Regulation Of Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization Negative Regulation Of Translation RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Regulation Of Angiogenesis Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cytokine Production Regulation Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Extracellular Space Regulation Of Metabolic Process Regulation Of Cell Migration Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration
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