SRSF10 and SRSF4

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		SRSF10	SRSF4
Description		serine and arginine rich splicing factor 10	serine and arginine rich splicing factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Dendrite Neuronal Cell Body Axon Terminus	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RS Domain Binding Unfolded Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Sequence-specific MRNA Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription MRNA Splice Site Recognition MRNA Processing RNA Splicing Cytosolic Transport Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Insulin Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs			Artenimol
Diseases
GWAS		Chronotype ( 30696823) Obesity-related traits ( 23251661)	Carotid plaque maximum area ( 32469969) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean area of carotid plaque ( 32469969) Schizophrenia ( 26531332) Tourette syndrome ( 30818990)
Interacting Genes		24 interacting genes: CLK1 CLK2 CLK3 CLK4 CSNK2A1 DAPK1 DYRK1A EXOSC8 FBXO7 FUS H19 MPP1 PTPN11 SNRNP70 SREK1 SRPK1 SRSF1 SRSF4 SUN2 SYCE1L TRA2A TRA2B YWHAB YWHAG	28 interacting genes: CPSF7 DYRK1A ERAL1 FUS GEMIN2 HAP1 HTATSF1 NXF1 PNN PPARGC1A PRPF38A PRRC2B SART1 SCAF11 SMURF1 SMURF2 SREK1 SRPK1 SRRM2 SRRM4 SRSF10 SRSF2 SRSF6 TICAM1 TRA2B UBE2I USP7 ZDHHC17
Entrez ID		10772	6429
HPRD ID		05562	09052
Ensembl ID		ENSG00000188529	ENSG00000116350
Uniprot IDs		A0A0S2Z504 B3KNY6 O75494 Q5JRI1	Q08170
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Protein Serine/threonine/tyrosine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity RNA Splicing Protein Serine/threonine Kinase Activity MRNA Metabolic Process Nuclear Speck Protein Kinase Activity Nucleus Protein Tyrosine Kinase Activity Kinase Activity RNA Processing Regulation Of Gene Expression MRNA Processing RNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Spliceosomal Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Identical Protein Binding Nucleic Acid Binding RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Phosphorylation Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Protein Targeting Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Binding ATP Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Autophosphorylation Negative Regulation Of RNA Splicing Negative Regulation Of Gene Expression Regulation Of Response To Tumor Cell Positive Regulation Of Metabolic Process	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Splicing, Via Transesterification Reactions Nuclear Speck RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleic Acid Binding Regulation Of MRNA Metabolic Process Spliceosomal Complex Assembly Nucleus Protein-containing Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Protein-containing Complex Organization Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process PML Body Cellular Component Assembly Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Pre-mRNA Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Binding Nuclear Export MRNA Splice Site Recognition Wnt Signaling Pathway, Planar Cell Polarity Pathway Histone H3T45 Kinase Activity SUMO Conjugating Enzyme Activity Positive Regulation Of Neurotrophin Production Maturation Of 5S RRNA Perforant Pathway To Dendrate Granule Cell Synapse Engulfment Of Target By Autophagosome Positive Regulation Of RNA Splicing Regulation Of Amyloid-beta Formation
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