SRSF10 and CLK4

Number of citations of the paper that reports this interaction (PubMedID 34316707)
67

Data Source:
BioGRID (enzymatic study)

		SRSF10	CLK4
Description		serine and arginine rich splicing factor 10	CDC like kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Dendrite Neuronal Cell Body Axon Terminus	Nucleus
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RS Domain Binding Unfolded Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription MRNA Splice Site Recognition MRNA Processing RNA Splicing Cytosolic Transport Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome	Regulation Of RNA Splicing
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs			Fostamatinib
Diseases
GWAS		Chronotype ( 30696823) Obesity-related traits ( 23251661)	Urate levels in obese individuals ( 25811787)
Interacting Genes		24 interacting genes: CLK1 CLK2 CLK3 CLK4 CSNK2A1 DAPK1 DYRK1A EXOSC8 FBXO7 FUS H19 MPP1 PTPN11 SNRNP70 SREK1 SRPK1 SRSF1 SRSF4 SUN2 SYCE1L TRA2A TRA2B YWHAB YWHAG	15 interacting genes: CLASRP HSPB2 KPNA1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 MITF RNF181 SRPK1 SRRM4 SRSF1 SRSF10 UBL5
Entrez ID		10772	57396
HPRD ID		05562	12140
Ensembl ID		ENSG00000188529	ENSG00000113240
Uniprot IDs		A0A0S2Z504 B3KNY6 O75494 Q5JRI1	Q9HAZ1
PDB IDs			6FYV
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Protein Serine/threonine/tyrosine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity RNA Splicing Protein Serine/threonine Kinase Activity MRNA Metabolic Process Nuclear Speck Protein Kinase Activity Nucleus Protein Tyrosine Kinase Activity Kinase Activity RNA Processing Regulation Of Gene Expression MRNA Processing RNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Spliceosomal Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Identical Protein Binding Nucleic Acid Binding RNA Splicing, Via Transesterification Reactions Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Protein Phosphorylation Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Phosphorylation Positive Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Protein Targeting Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Binding ATP Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Autophosphorylation Negative Regulation Of RNA Splicing Negative Regulation Of Gene Expression Regulation Of Response To Tumor Cell Positive Regulation Of Metabolic Process	Keratin Filament Intermediate Filament RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Metabolic Process RS Domain Binding Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Binding Melanocyte Apoptotic Process Protein Localization To P-body Satellite Cell Activation Involved In Skeletal Muscle Regeneration Somatic Muscle Development Negative Regulation Of MRNA Metabolic Process DNA Topoisomerase Binding
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