PLK2 and CIB1

Number of citations of the paper that reports this interaction (PMID 10523297)
47

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		PLK2	CIB1
Gene Name		polo-like kinase 2	calcium and integrin binding 1 (calmyrin)
Image
Gene Ontology Annotations	Cellular Component	Intracellular Centrosome Centriole Dendrite	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding Protein Complex Binding	Calcium Ion Binding Protein Binding Ras GTPase Binding Protein Anchor Ion Channel Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long Term Synaptic Depression Negative Regulation Of Dendritic Spine Development	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Metalloenzyme Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA	21 interactors: AURKB CDK4 EXOSC10 FEZ1 IFI6 ITGA2B ITGB3 NBR1 NRIP1 PAX3 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 TERT UBR5 WAS ZDHHC17
Entrez ID		10769	10519
HPRD ID		06118	03800
Ensembl ID		ENSG00000145632
Uniprot IDs		Q9NYY3	H6WJF3 Q99828
PDB IDs		4I6H	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
Enriched GO Terms of Interacting Partners?		Synapse Organization Positive Regulation Of Transport Positive Regulation Of Intracellular Transport Receptor Internalization Negative Regulation Of Microtubule Polymerization Or Depolymerization Neuromuscular Junction Development Nucleotide Phosphorylation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Microtubule Polymerization Or Depolymerization Cell Adhesion Regulation Of Intracellular Transport Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Posttranscriptional Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Receptor Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Transmission Of Virus Development Involved In Symbiotic Interaction Nucleobase-containing Compound Metabolic Process Regulation Of Synapse Structure Or Activity Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Regulation Of Neuron Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Nucleotide Metabolic Process Regulation Of Gene Expression Adult Locomotory Behavior Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell-matrix Adhesion Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Thrombopoietin-mediated Signaling Pathway Regulation Of Ion Transport Nucleobase-containing Small Molecule Metabolic Process Endocytosis Regulation Of Protein Stability Cell Activation	Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cell Death Homotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cell Death Cell Activation Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Neuron Differentiation Generation Of Neurons Developmental Process Single Organismal Cell-cell Adhesion Signaling Neurogenesis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Binding Nervous System Development Cell Development Neuron Development Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Component Organization Axon Guidance Organelle Organization Cell Death Movement Of Cell Or Subcellular Component Death Positive Regulation Of Cellular Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cell Cycle
Tagcloud ?		acts apoptosisassociated bax bgc823 caspase centrosome downregulated elucidated exerted gastric hepatocarcinogenesis inhibiting interfering mitosis mkn45 myeloblastic overexpressed pololike serine sgc7901 si silencing sirnatransfected stages suppressor threonine transfection untransfected vital	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Difference) ?		acts apoptosisassociated bax bgc823 caspase centrosome downregulated elucidated exerted gastric hepatocarcinogenesis inhibiting interfering mitosis mkn45 myeloblastic overexpressed pololike serine sgc7901 si silencing sirnatransfected stages suppressor threonine transfection untransfected vital	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Intersection) ?