PLK2 and CDC20B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PLK2	CDC20B
Description		polo like kinase 2	cell division cycle 20B
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Dendrite Cell Projection	Anaphase-promoting Complex Cytoplasm Deuterosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Protein Binding Protein Serine Kinase Activity	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin Ligase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Mitotic Spindle Organization Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Negative Regulation Of Angiogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence	Anaphase-promoting Complex-dependent Catabolic Process De Novo Centriole Assembly Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response NPAS4 regulates expression of target genes
Drugs		Fostamatinib
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Multisite chronic pain ( 33830993) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)	Cocaine dependence ( 31212010)
Interacting Genes		16 interacting genes: AP1B1 AP1G1 AP2A1 APP CASK CDC20B CENPU CIB1 DNM1 MPP3 NEDD4 NRIP1 NSF TSC1 TSC2 TUBA1A	21 interacting genes: CCDC57 FHL5 GEMIN4 GOLGA2 KANK2 KRT31 KRT34 KRT40 MAGEA11 MDFI MTUS2 NUTM1 PLEKHF2 PLK2 SPAG5 TACC3 TRAF2 TRIM23 TRIM27 TRIM37 VPS52
Entrez ID		10769	166979
HPRD ID		06118	13428
Ensembl ID		ENSG00000145632	ENSG00000164287
Uniprot IDs		A0A087WUH9 Q9NYY3	Q86Y33
PDB IDs		4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Intracellular Protein Transport Endocytosis Membrane Coat Establishment Of Localization In Cell TSC1-TSC2 Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Vesicle-mediated Transport Basolateral Protein Secretion Import Into Cell Lysosomal Membrane Cellular Localization Protein Transport Perinuclear Region Of Cytoplasm Positive Regulation Of Protein Catabolic Process Clathrin Adaptor Complex AP-1 Adaptor Complex Adult Locomotory Behavior Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Synapse Organization Establishment Of Protein Localization Associative Learning Golgi Apparatus Filopodium Tip Clathrin Adaptor Activity Post-Golgi Vesicle-mediated Transport Melanosome Assembly Synapse Positive Regulation Of Catabolic Process Trans-Golgi Network Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-matrix Adhesion Platelet Dense Granule Organization Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Regulation Of Transport Regulation Of Protein Catabolic Process Adult Behavior Ionotropic Glutamate Receptor Binding Negative Regulation Of Cell Population Proliferation Learning Cytosol Vesicle Budding From Membrane Clathrin-coated Vesicle Membrane Receptor-mediated Endocytosis Melanosome Organization Negative Regulation Of Macroautophagy Pigment Granule Organization	Spindle Organization Cytoskeleton Organization Spindle Pole Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Mitotic Spindle Organization Microtubule Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin-protein Transferase Activity Regulation Of Microtubule-based Process Establishment Of Localization In Cell Intracellular Transport Organelle Organization Regulation Of Cytoskeleton Organization Regulation Of Centriole Replication Microtubule Cytoskeleton Organization Involved In Mitosis Centriolar Satellite Mitotic Spindle Microtubule Nucleation Tumor Necrosis Factor Receptor Binding Ubiquitin Protein Ligase Activity Mitotic Cell Cycle Phase Transition Regulation Of Autophagy Intermediate Filament Cell Cycle Phase Transition Centrosome Positive Regulation Of Autophagy Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly Structural Molecule Activity Regulation Of Cell Cycle Cellular Localization Regulation Of Centrosome Duplication Regulation Of Cell Cycle Process Syntaxin Binding Microtubule-based Process Regulation Of Centrosome Cycle Regulation Of Organelle Organization TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Vitamin D Receptor Signaling Pathway Supramolecular Fiber Organization Spindle Microtubule Binding Protein Autoubiquitination Regulation Of Organelle Assembly
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