PLK2

Gene Name		polo-like kinase 2
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Gene Ontology Annotations	Cellular Component	Intracellular Centrosome Centriole Dendrite
	Molecular Function	Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding Protein Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Spindle Organization Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Memory Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long Term Synaptic Depression Negative Regulation Of Dendritic Spine Development
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: APP CASK CDC20B CENPU CIB1 MPP3 NEDD4 SNCA
Entrez ID		10769
HPRD ID		06118
Ensembl ID		ENSG00000145632
Uniprot IDs		Q9NYY3
PDB IDs		4I6H
Enriched GO Terms of Interacting Partners?		Synapse Organization Positive Regulation Of Transport Positive Regulation Of Intracellular Transport Receptor Internalization Negative Regulation Of Microtubule Polymerization Or Depolymerization Neuromuscular Junction Development Nucleotide Phosphorylation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Microtubule Polymerization Or Depolymerization Cell Adhesion Regulation Of Intracellular Transport Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Posttranscriptional Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Receptor Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Transmission Of Virus Development Involved In Symbiotic Interaction Nucleobase-containing Compound Metabolic Process Regulation Of Synapse Structure Or Activity Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Regulation Of Neuron Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Nucleotide Metabolic Process Regulation Of Gene Expression Adult Locomotory Behavior Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell-matrix Adhesion Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Thrombopoietin-mediated Signaling Pathway Regulation Of Ion Transport Nucleobase-containing Small Molecule Metabolic Process Endocytosis Regulation Of Protein Stability Cell Activation
Tagcloud ?		acts apoptosisassociated bax bgc823 caspase centrosome downregulated elucidated exerted gastric hepatocarcinogenesis inhibiting interfering mitosis mkn45 myeloblastic overexpressed pololike serine sgc7901 si silencing sirnatransfected stages suppressor threonine transfection untransfected vital