PLK2 and CENPU

Number of citations of the paper that reports this interaction (PubMedID 19597481)
23

Data Source:
BioGRID (unspecified method)

		PLK2	CENPU
Description		polo like kinase 2	centromere protein U
Image
GO Annotations	Cellular Component	Kinetochore Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Dendrite Cell Projection	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Centriolar Satellite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Protein Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Mitotic Spindle Organization Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Negative Regulation Of Angiogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence	Chromosome Segregation Chordate Embryonic Development
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response NPAS4 regulates expression of target genes	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Multisite chronic pain ( 33830993) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)
Interacting Genes		16 interacting genes: AP1B1 AP1G1 AP2A1 APP CASK CDC20B CENPU CIB1 DNM1 MPP3 NEDD4 NRIP1 NSF TSC1 TSC2 TUBA1A	20 interacting genes: CENPQ E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 OGT PGRMC1 PLK1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		10769	79682
HPRD ID		06118	14722
Ensembl ID		ENSG00000145632	ENSG00000151725
Uniprot IDs		A0A087WUH9 Q9NYY3	Q71F23
PDB IDs		4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0	7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH 8K4D
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Intracellular Protein Transport Endocytosis Membrane Coat Establishment Of Localization In Cell TSC1-TSC2 Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Vesicle-mediated Transport Basolateral Protein Secretion Import Into Cell Lysosomal Membrane Cellular Localization Protein Transport Perinuclear Region Of Cytoplasm Positive Regulation Of Protein Catabolic Process Clathrin Adaptor Complex AP-1 Adaptor Complex Adult Locomotory Behavior Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Synapse Organization Establishment Of Protein Localization Associative Learning Golgi Apparatus Filopodium Tip Clathrin Adaptor Activity Post-Golgi Vesicle-mediated Transport Melanosome Assembly Synapse Positive Regulation Of Catabolic Process Trans-Golgi Network Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-matrix Adhesion Platelet Dense Granule Organization Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Regulation Of Transport Regulation Of Protein Catabolic Process Adult Behavior Ionotropic Glutamate Receptor Binding Negative Regulation Of Cell Population Proliferation Learning Cytosol Vesicle Budding From Membrane Clathrin-coated Vesicle Membrane Receptor-mediated Endocytosis Melanosome Organization Negative Regulation Of Macroautophagy Pigment Granule Organization	Regulation Of Cellular Component Organization Spindle Pole Regulation Of Cytokinesis Positive Regulation Of Protein Localization Regulation Of Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Division Regulation Of Protein Localization Centrosome Separation Regulation Of Protein-containing Complex Assembly Cytoskeleton Regulation Of Cell Cycle Negative Regulation Of Cellular Component Organization Negative Regulation Of Synapse Organization Cell Junction Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle Organization Synapse Organization Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Synapse Organization Regulation Of Centriole Replication Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Organization Regulation Of Protein Catabolic Process Centrosome Cell Cycle Phase Transition Kinetochore Regulation Of Synapse Assembly Negative Regulation Of Catabolic Process Positive Regulation Of Translation Regulation Of Microtubule Cytoskeleton Organization Mitotic Spindle Pole Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Autophagy Regulation Of Protein Metabolic Process Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
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