KIF1C and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 9685376)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		KIF1C	PTPN21
Description		kinesin family member 1C	protein tyrosine phosphatase non-receptor type 21
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytoskeleton Kinesin Complex Microtubule Axon Dendrite Axon Cytoplasm	Cytoplasm Cytoskeleton
	Molecular Function	Nucleotide Binding RNA Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Vesicle-mediated Transport Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport	Protein Dephosphorylation
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Spleen volume ( 34128465)	Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		10 interacting genes: CSNK2A1 CSNK2A2 LAMC3 PTPN21 RNF10 TSC1 YWHAB YWHAE YWHAG YWHAZ	27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		10749	11099
HPRD ID		04342	04468
Ensembl ID		ENSG00000129250	ENSG00000070778
Uniprot IDs		O43896	Q16825
PDB IDs		2G1L 9KO8	8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Sequestering Activity Protein Targeting Protein Kinase CK2 Complex Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of TORC1 Signaling TORC1 Signaling Protein Domain Specific Binding Cerebral Cortex Development TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Melanosome Regulation Of Protein Stability Focal Adhesion Regulation Of Protein Localization Regulation Of TOR Signaling Cellular Response To Stress PcG Protein Complex Cellular Response To Starvation Regulation Of Macroautophagy Phosphoprotein Binding Hsp90 Protein Binding Response To Starvation Protein Catabolic Process Protein Stabilization Protein Phosphatase Inhibitor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Cellular Response To Nutrient Levels Regulation Of Signal Transduction Signal Transduction Establishment Of Protein Localization Negative Regulation Of Proteasomal Protein Catabolic Process Memory T Cell Differentiation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of TORC1 Signaling Negative Regulation Of Intracellular Signal Transduction Cadherin Binding Hippocampus Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Chromosome Separation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Autophagy	Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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