RAI1 and ULK2

		RAI1	ULK2
Description		retinoic acid induced 1	unc-51 like autophagy activating kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Phagophore Assembly Site Cytoplasm Autophagosome Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Phagophore Assembly Site Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of DNA-templated Transcription Rhythmic Process	Autophagosome Assembly Mitophagy Autophagy Signal Transduction Nervous System Development Axonogenesis Axon Guidance Intracellular Protein Localization Regulation Of Autophagy Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Collateral Sprouting Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Somatic Sensory System Development
Pathways		Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Fostamatinib
Diseases		Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		A body shape index ( 34021172) Body mass index ( 28892062) Caffeine consumption from coffee ( 33287642) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Glycated hemoglobin levels ( 34059833) Hip circumference ( 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 27863252) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 29483656 28991256 25056061) Type 2 diabetes ( 30054458 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ZNF496	15 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32
Entrez ID		10743	9706
HPRD ID		07406	10556
Ensembl ID		ENSG00000108557	ENSG00000083290
Uniprot IDs		Q7Z5J4	Q8IYT8
PDB IDs			6QAT 6QAU 6QAV 6YID
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II ER Overload Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Signaling Pathway Megakaryocyte Differentiation Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Nucleoplasm Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Growth Intracellular Signaling Cassette Regeneration Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Response To Ionizing Radiation Regulation Of JNK Cascade Positive Regulation Of Biosynthetic Process Mitotic G2 DNA Damage Checkpoint Signaling Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Developmental Process ER-nucleus Signaling Pathway Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	Mitophagy Autophagosome Autophagy Of Mitochondrion Response To Mitochondrial Depolarisation Macroautophagy Autophagosome Maturation Autophagosome Membrane Protein Transport Cellular Response To Nitrogen Starvation Intracellular Protein Localization Establishment Of Protein Localization Phosphatidylethanolamine Binding Autophagosome Assembly Regulation Of Protein Complex Stability GABA Receptor Binding Autophagosome Organization Autophagy Protein Import Into Nucleus Import Into Nucleus Protein Localization To Organelle Establishment Of Protein Localization To Organelle Protein-containing Complex Disassembly Phagophore Assembly Site Vacuole Organization Protein Localization To Nucleus Cellular Response To Starvation Beta-tubulin Binding Regulation Of Ras Protein Signal Transduction Protein Targeting Sperm Midpiece Extrinsic Component Of Phagophore Assembly Site Membrane Protein Targeting To Vacuole Response To Starvation Intracellular Protein Transport Nuclear Transport Nucleocytoplasmic Transport Synapse Organization Establishment Of Protein Localization To Vacuole Cellular Response To Nutrient Levels Brown Fat Cell Proliferation Amphisome Extrinsic Component Of Omegasome Membrane Regulation Of Small GTPase Mediated Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Protein K48-linked Ubiquitination Protein Localization To Vacuole Eukaryotic Translation Elongation Factor 1 Complex Organelle Assembly Histone H3K9 Trimethyltransferase Activity
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