HSD11B1

Description		hydroxysteroid 11-beta dehydrogenase 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Steroid Binding Oxidoreductase Activity Protein Homodimerization Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity NADP Binding 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Cortisol Dehydrogenase (NADP+) Activity
	Biological Process	Lipid Metabolic Process Steroid Catabolic Process Steroid Metabolic Process Lung Development
Pathways		Glucocorticoid biosynthesis Prednisone ADME
Drugs		NADH Carbenoxolone Nicotinamide adenine dinucleotide phosphate 2-(N-morpholino)ethanesulfonic acid Corticosterone INCB13739 (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone (5S)-2-{[(1S)-1-(4-Fluorophenyl)ethyl]amino}-5-(2-hydroxy-2-propanyl)-5-methyl-1,3-thiazol-4(5H)-one (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide (5S)-2-(Cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE (5R)-2-[(2-Fluorophenyl)amino]-5-isopropyl-1,3-thiazol-4(5H)-one Glycyrrhizic acid
Diseases		Cortisone reductase deficiency (CRD)
GWAS		Alopecia areata ( 25608926)
Novel Interacting Genes		1 novel interacting genes: CENPF
Interacting Genes		2 interacting genes: CD36 GKAP1
Entrez ID		3290
HPRD ID		07042
Ensembl ID		ENSG00000117594
Uniprot IDs		P28845 X5D2L1
PDB IDs		1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 4C7J 4C7K 4HFR 4HX5 4IJU 4IJV 4IJW 4K1L 4P38 4YYZ 5PGU 5PGV 5PGW 5PGX 5PGY 5QII
Enriched GO Terms of Interacting Partners?		CGMP-mediated Signaling Oleate Transmembrane Transporter Activity Short-chain Fatty Acid Transport Response To Linoleic Acid Lipoteichoic Acid Immune Receptor Activity Long-chain Fatty Acid Import Across Plasma Membrane Thrombospondin Receptor Activity Short-chain Fatty Acid Transmembrane Transporter Activity Positive Regulation Of Blood Microparticle Formation Oxidised Low-density Lipoprotein Particle Receptor Activity Triglyceride Transport Low-density Lipoprotein Particle Mediated Signaling Oxidised Low-density Lipoprotein Particle Clearance Intestinal Cholesterol Absorption Response To Bacterial Lipoprotein Positive Regulation Of Cholesterol Storage Lipoprotein Particle Binding Intracellular Signal Transduction Cellular Response To Lipoteichoic Acid Regulation Of Removal Of Superoxide Radicals Regulation Of Response To Reactive Oxygen Species Response To Stilbenoid Nitric Oxide-cGMP-mediated Signaling Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cholesterol Import Intestinal Lipid Absorption Amyloid-beta Clearance By Cellular Catabolic Process Toll-like Receptor Binding Cellular Response To Hydroperoxide Long-chain Fatty Acid Import Into Cell Cellular Response To Bacterial Lipopeptide Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Phagocytosis, Engulfment Lipid Transport Across Blood-brain Barrier Cellular Response To Diacyl Bacterial Lipopeptide Lipid Import Into Cell High-density Lipoprotein Particle Binding Phagocytosis, Recognition Kinetochore Assembly Ciliary Transition Fiber Pronucleus Low-density Lipoprotein Particle Receptor Activity Low-density Lipoprotein Particle Clearance Lipoprotein Transport Low-density Lipoprotein Particle Binding Platelet Alpha Granule Membrane Long-chain Fatty Acid Transmembrane Transporter Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Kinetochore Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation
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