HSD11B1

Gene Name		hydroxysteroid (11-beta) dehydrogenase 1
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	11-beta-hydroxysteroid Dehydrogenase [NAD(P)] Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Glucocorticoid Biosynthetic Process Steroid Metabolic Process Lung Development Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Metabolism of lipids and lipoproteins Glucocorticoid biosynthesis Metabolism of steroid hormones and vitamin D
Drugs		NADH Prednisone Carbenoxolone 2\'-Monophosphoadenosine 5\'-Diphosphoribose 2-(N-Morpholino)-Ethanesulfonic Acid (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide (5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one
Diseases
GWAS
Protein-protein Interactions		2 interactors: CD36 GKAP1
Entrez ID		3290
HPRD ID		07042
Ensembl ID		ENSG00000117594
Uniprot IDs		P28845
PDB IDs		1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 4HFR 4HX5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Blood Microparticle Formation Low-density Lipoprotein Particle Mediated Signaling Plasma Membrane Long-chain Fatty Acid Transport Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoprotein Particle Stimulus Long-chain Fatty Acid Import Response To Low-density Lipoprotein Particle Response To Stilbenoid Cellular Response To Lipoteichoic Acid Regulation Of Removal Of Superoxide Radicals Cellular Response To Hydroperoxide CGMP-mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Phagocytosis, Recognition Response To Lipoprotein Particle Positive Regulation Of Cholesterol Storage Lipoprotein Transport Positive Regulation Of Macrophage Cytokine Production Nitric Oxide Mediated Signal Transduction Response To Hydroperoxide Low-density Lipoprotein Particle Clearance Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Negative Regulation Of Growth Of Symbiont In Host Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Blood Coagulation Apoptotic Cell Clearance Positive Regulation Of Lipid Storage Plasma Lipoprotein Particle Clearance Cyclic-nucleotide-mediated Signaling Positive Regulation Of Coagulation Lipid Storage Positive Regulation Of Interleukin-12 Production Regulation Of Macrophage Derived Foam Cell Differentiation Long-chain Fatty Acid Transport Positive Regulation Of Wound Healing Positive Regulation Of Phagocytosis Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Lipid Storage Positive Regulation Of Cell-matrix Adhesion Regulation Of Plasma Lipoprotein Particle Levels Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Phagocytosis Regulation Of Interleukin-12 Production
Tagcloud ?		11beta adipose adrenal appearance caucasian clearance confounded cortisol cortisone d3 deuterated dysregulation excretion hydroxysteroid hypothalamic invoked metabolite metabolites obesity ovary overweight pcos polycystic rs12086634 rs846910 steady subcutaneous unmedicated