USP16 and SGIP1

		USP16	SGIP1
Description		ubiquitin specific peptidase 16	SH3GL interacting endocytic adaptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane AP-2 Adaptor Complex Clathrin-coated Vesicle Presynapse
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Ribosomal Small Subunit Binding Ubiquitin Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	Protein Binding Phospholipid Binding Microtubule Binding Tubulin Binding SH3 Domain Binding
	Biological Process	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis DNA Damage Response Regulation Of Gene Expression Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Positive Regulation Of Ribosome Biogenesis Mitotic Nuclear Division	Response To Dietary Excess Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Energy Homeostasis Positive Regulation Of Feeding Behavior
Pathways		Ub-specific processing proteases	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Automobile speeding propensity ( 30643258) Cerebellum white matter volume ( 31530798) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronotype ( 30696823) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Menopause (age at onset) ( 23307926) Presence of antiphospholipid antibodies ( 23509613) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418) TPE interval (resting) ( 32386560) Ulcerative colitis ( 28067908)
Interacting Genes		23 interacting genes: CALM1 CDK1 DNM1L EXOSC10 FAU FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4C16 ISG15 LINC02381 PAX6 PLK1 PTOV1 SATB1 TTK UBC UBD XRN2 ZEB2	2 interacting genes: APP DAB2
Entrez ID		10600	84251
HPRD ID		06881	10910
Ensembl ID		ENSG00000156256	ENSG00000118473
Uniprot IDs		Q9Y5T5	A0A804HHV6 A0A804HI01 A0A804HJG4 A0A804HJX5 B7Z691 Q9BQI5
PDB IDs		2I50 8WG5	5AWR 5AWS 5AWT 5AWU 6A9Y
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Chromatin Remodeling Protein Tag Activity Chromosome Regulation Of Chromosome Organization Chromatin Organization Post-translational Protein Modification Protein Ubiquitination Protein Localization To Organelle Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Heterodimerization Activity Female Meiosis Chromosome Segregation Regulation Of Sister Chromatid Segregation Spindle Microtubule Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Chromosome Segregation G2/M Transition Of Mitotic Cell Cycle Heterochromatin Formation Protein Localization To Chromatin Nucleoplasm Nucleus Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Mitotic Nuclear Membrane Disassembly Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Telomerase RNA Localization To Cajal Body Protein Localization To Kinetochore Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Meiotic Chromosome Segregation Nuclear Membrane Disassembly Negative Regulation Of Biosynthetic Process Membrane Disassembly Negative Regulation Of Chromosome Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Protein Localization To Nucleus	Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Protein Homooligomerization Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Pit Positive Regulation Of Small Molecule Metabolic Process Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Aldosterone Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Aldosterone Secretion Positive Regulation Of Ribosome Biogenesis Protein-containing Complex Organization Regulation Of Canonical Wnt Signaling Pathway Protein Complex Oligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Translational Elongation Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade
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