SGIP1

Description		SH3GL interacting endocytic adaptor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane AP-2 Adaptor Complex Clathrin-coated Vesicle Presynapse
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Tubulin Binding SH3 Domain Binding
	Biological Process	Response To Dietary Excess Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Energy Homeostasis Positive Regulation Of Feeding Behavior
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Automobile speeding propensity ( 30643258) Cerebellum white matter volume ( 31530798) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronotype ( 30696823) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Menopause (age at onset) ( 23307926) Presence of antiphospholipid antibodies ( 23509613) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418) TPE interval (resting) ( 32386560) Ulcerative colitis ( 28067908)
Novel Interacting Genes		1 novel interacting genes: USP16
Interacting Genes		2 interacting genes: APP DAB2
Entrez ID		84251
HPRD ID		10910
Ensembl ID		ENSG00000118473
Uniprot IDs		A0A804HHV6 A0A804HI01 A0A804HJG4 A0A804HJX5 B7Z691 Q9BQI5
PDB IDs		5AWR 5AWS 5AWT 5AWU 6A9Y
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Protein Homooligomerization Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Pit Positive Regulation Of Small Molecule Metabolic Process Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Aldosterone Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Aldosterone Secretion Positive Regulation Of Ribosome Biogenesis Protein-containing Complex Organization Regulation Of Canonical Wnt Signaling Pathway Protein Complex Oligomerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Translational Elongation Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade
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