INSM1

Description		INSM transcriptional repressor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Cyclin Binding Chromatin DNA Binding Histone Deacetylase Binding Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Phosphorylation Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Type B Pancreatic Cell Development Noradrenergic Neuron Development Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Cell Cycle Process Cell Migration Cell Differentiation Neuron Differentiation Positive Regulation Of Cell Migration Endocrine Pancreas Development Endocrine System Development Regulation Of Cell Population Proliferation Norepinephrine Biosynthetic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of Cell Cycle Transdifferentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: CCND1 KDM1A MPP3 SORBS1 TUBB3
Entrez ID		3642
HPRD ID		02480
Ensembl ID		ENSG00000173404
Uniprot IDs		Q01101
PDB IDs		2LV2 3ZMS 8JPY 8JQ1 8K81
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Transcription Corepressor Activity Response To UV Re-entry Into Mitotic Cell Cycle Response To Ionizing Radiation Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Adherens Junction Netrin Receptor Binding Dorsal Root Ganglion Development Response To Fungicide MRF Binding Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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