HIST1H3C and UHRF1

Number of citations of the paper that reports this interaction (PMID 17967883)
56

Data Source:
BioGRID (enzymatic study)

		HIST1H3C	UHRF1
Gene Name		histone cluster 1, H3c	ubiquitin-like with PHD and ring finger domains 1
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Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nuclear Chromatin Euchromatin Heterochromatin Nucleus Replication Fork Nuclear Matrix
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Ligase Activity Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Silencing At RDNA Chromatin Organization DNA Replication-dependent Nucleosome Assembly Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Transcription, DNA-templated Cell Cycle Cell Proliferation Maintenance Of DNA Methylation Histone Monoubiquitination Gene Expression Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Epigenetic regulation of gene expression DNA methylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ASF1A ASF1B CBX1 CENPA DAXX PHF1 TRIM24 UHRF1	22 interactors: BTRC DNMT1 DNMT3A H3F3A H3F3B HIST1H2AB HIST1H2BB HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST3H3 KAT5 MBD4 PARP1 PRKACA
Entrez ID		8352	29128
HPRD ID		11906	06992
Ensembl ID		ENSG00000196532
Uniprot IDs		P68431	Q96T88
PDB IDs		1CS9 1CT6 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2KWJ 2KWK 2L75 2LBM 2M0O 2RI7 2UXN 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3KMT 3KQI 3LQI 3LQJ 3O34 3O35 3O37 3RIG 3RIY 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4F4U 4F56 4FWF 4HON 4I51	2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Replication-independent Nucleosome Assembly Chromosome Organization DNA Packaging DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Gene Expression Protein Complex Assembly Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Histone H3-K27 Methylation Chromatin Remodeling Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Vitamin D Receptor Signaling Pathway Cellular Component Assembly Cellular Response To DNA Damage Stimulus Negative Regulation Of Chromatin Silencing Positive Regulation Of Metabolic Process	DNA Methylation On Cytosine Chromatin Silencing At RDNA DNA Modification Chromatin Silencing DNA Methylation Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Methylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated DNA Replication-dependent Nucleosome Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleosome Assembly Chromosome Organization Negative Regulation Of Gene Expression Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Organization Protein-DNA Complex Assembly DNA Packaging Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Regulation Of Body Fluid Levels DNA Conformation Change Wound Healing Regulation Of Gene Silencing Response To Wounding Gene Expression Cellular Macromolecular Complex Assembly Organelle Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Complex Assembly Nitrogen Compound Metabolic Process Response To Stress Regulation Of Gene Expression Cellular Component Assembly Regulation Of Metabolic Process
Tagcloud ?			24hrs acetyl acetylated aptx caco cdkn1a characterised cyanotoxin cylindrospermopsin cyn dimethylated ehmt2 emerging h2a highlighted histones initiating kat5 lys4 lys5 methyltransferases modifying myst1 nucleosomal pms2 recognised recombination remodelling transcriptomic
Tagcloud (Difference) ?			24hrs acetyl acetylated aptx caco cdkn1a characterised cyanotoxin cylindrospermopsin cyn dimethylated ehmt2 emerging h2a highlighted histones initiating kat5 lys4 lys5 methyltransferases modifying myst1 nucleosomal pms2 recognised recombination remodelling transcriptomic
Tagcloud (Intersection) ?