AGPAT2 and ANKRD28

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AGPAT2	ANKRD28
Description		1-acylglycerol-3-phosphate O-acyltransferase 2	ankyrin repeat domain 28
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Serine/threonine Phosphatase Complex Lamellipodium Cell Projection
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Epidermis Development Phospholipid Biosynthetic Process Response To Xenobiotic Stimulus CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process	Positive Regulation Of Focal Adhesion Assembly
Pathways		Synthesis of PA Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Telomere Extension By Telomerase COPII-mediated vesicle transport
Drugs
Diseases		Congenital generalized lipodystrophy (CGL)
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: ABCG8 ANKRD28 GMPS PHF11 PHRF1 SLC23A2	34 interacting genes: ABCF2 AGPAT2 ANK2 ANKRD26 ANKRD50 BCL3 BRCA1 CCDC187 CD164 CSNK2B EEF1G EHMT2 EIF3D GADD45GIP1 HNRNPK HNRNPR INCA1 KCNV2 MYOM1 NOTCH2 NOTCH3 PIBF1 PTRH1 RNF11 TGM2 TGS1 THAP7 TMIE TNKS TNKS2 TTN UACA YTHDC1 ZNF512B
Entrez ID		10555	23243
HPRD ID		04373	10651
Ensembl ID		ENSG00000169692	ENSG00000206560
Uniprot IDs		A0A024R8F9 O15120	O15084
PDB IDs
Enriched GO Terms of Interacting Partners?		GMP Synthase (glutamine-hydrolyzing) Activity GMP Synthase Activity L-ascorbic Acid Transmembrane Transport L-ascorbic Acid Transmembrane Transporter Activity L-ascorbate:sodium Symporter Activity Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Purine Nucleobase Biosynthetic Process L-ascorbic Acid Metabolic Process Protein Serine/threonine Phosphatase Complex Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption GMP Biosynthetic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cellular Response To Ethanol Apical Plasma Membrane Positive Regulation Of Dendrite Extension Vitamin Transmembrane Transport RNA Polymerase Binding	M Band Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Telomere Capping Glomerular Capillary Formation Enzyme Binding Marginal Zone B Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Formation Cellular Response To Cocaine Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Protein Kinase A Signaling NAD+-protein-glutamate ADP-ribosyltransferase Activity Random Inactivation Of X Chromosome NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Capping C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Kinase Regulator Activity Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Poly-ADP-ribosylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-threonine Phosphorylation NAD+-protein Mono-ADP-ribosyltransferase Activity Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Receptor Signaling Pathway Via STAT Mature B Cell Differentiation Involved In Immune Response Protein Localization To T-tubule Nucleoplasm Bcl3-Bcl10 Complex Mature B Cell Differentiation Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
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