AGPAT2 and PHRF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AGPAT2	PHRF1
Description		1-acylglycerol-3-phosphate O-acyltransferase 2	PHD and ring finger domains 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase Binding
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Epidermis Development Phospholipid Biosynthetic Process Response To Xenobiotic Stimulus CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process	Protein Ubiquitination
Pathways		Synthesis of PA Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Congenital generalized lipodystrophy (CGL)
GWAS			Refractive error ( 32231278) Systemic lupus erythematosus ( 19838195 26502338)
Interacting Genes		6 interacting genes: ABCG8 ANKRD28 GMPS PHF11 PHRF1 SLC23A2	3 interacting genes: AGPAT2 H3-4 UBE2D2
Entrez ID		10555	57661
HPRD ID		04373	13870
Ensembl ID		ENSG00000169692	ENSG00000070047
Uniprot IDs		A0A024R8F9 O15120	B7ZM65 B7ZM66 E9PJ24 F8WEF5 Q9P1Y6
PDB IDs
Enriched GO Terms of Interacting Partners?		GMP Synthase (glutamine-hydrolyzing) Activity GMP Synthase Activity L-ascorbic Acid Transmembrane Transport L-ascorbic Acid Transmembrane Transporter Activity L-ascorbate:sodium Symporter Activity Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Purine Nucleobase Biosynthetic Process L-ascorbic Acid Metabolic Process Protein Serine/threonine Phosphatase Complex Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption GMP Biosynthetic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cellular Response To Ethanol Apical Plasma Membrane Positive Regulation Of Dendrite Extension Vitamin Transmembrane Transport RNA Polymerase Binding
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