NDUFB2 and LCN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NDUFB2	LCN2
Description		NADH:ubiquinone oxidoreductase subunit B2	lipocalin 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Extracellular Region Extracellular Space Cytoplasmic Vesicle Specific Granule Lumen Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Iron Ion Sequestering Activity Enterobactin Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Immune System Process Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Acute-phase Response Response To Oxidative Stress Short-term Memory Long-term Memory Response To Xenobiotic Stimulus Response To Virus Response To Bacterium Response To Herbicide Response To Toxic Substance Response To Blue Light Response To Fructose Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Response To Nutrient Levels Cellular Response To Nutrient Levels Response To Lipopolysaccharide Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To X-ray Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Kainic Acid Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Respiratory electron transport Complex I biogenesis	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs		NADH	Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS
Interacting Genes		6 interacting genes: AGR2 CDC7 LCN2 MEOX2 NDUFB7 PFKM	62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF CAMLG CCNC CDSN CHIC2 CIMIP1 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1
Entrez ID		4708	3934
HPRD ID		11953	02551
Ensembl ID		ENSG00000090266	ENSG00000148346
Uniprot IDs		A4D1T5 O95178	P80188
PDB IDs		5XTC 5XTD 5XTH 5XTI	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA 6Z2C 6Z6Z 8UYN 8UZ9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Response To Herbicide Positive Regulation Of Metabolic Process Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Siderophore Transport Cytoplasmic Vesicle Lumen Response To Mycotoxin Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Somite Specification ATP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds 6-phosphofructokinase Activity Fructose-6-phosphate Binding Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate 6-phosphofructokinase Complex Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Iron Ion Transport Response To Blue Light Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Fructose Binding Positive Regulation Of Nuclear Cell Cycle DNA Replication Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To X-ray Response To Fructose Dystroglycan Binding Purine Ribonucleotide Metabolic Process Short-term Memory Cellular Response To Increased Oxygen Levels Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Generation Of Precursor Metabolites And Energy Fructose 6-phosphate Metabolic Process Cellular Response To Interleukin-6 Segment Specification Somite Development Positive Regulation Of DNA-templated DNA Replication	Regulation Of Release Of Cytochrome C From Mitochondria TRC Complex Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Protein-disulfide Reductase Activity Regulation Of ERAD Pathway Protein Targeting To ER Regulation Of Protein Metabolic Process Proteolysis Response To UV Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Response To UV Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Cellular Response To UV-A Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Cellular Response To Light Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Response To UV-A
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