TNFRSF8 and CLCN6

		TNFRSF8	CLCN6
Description		TNF receptor superfamily member 8	chloride voltage-gated channel 6
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome	Lysosomal Membrane Endosome Endosome Membrane Membrane Late Endosome Membrane
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus	Monoatomic Ion Transport Chloride Transport Cell Volume Homeostasis Signal Transduction Response To Mechanical Stimulus Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		TNFs bind their physiological receptors	Stimuli-sensing channels Signaling by BRAF and RAF1 fusions
Drugs		Iratumumab XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Asthma ( 31959851 32296059 34103634) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)	Arterial stiffness index ( 31235810) Coronary artery disease ( 29212778) Diastolic blood pressure ( 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Natriuretic peptide levels ( 21273288) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red cell distribution width ( 32888494) Systolic blood pressure ( 19430483 29615537 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 28604728) Tuberculosis ( 29036319)
Interacting Genes		7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5	1 interacting genes: ERBB2
Entrez ID		943	1185
HPRD ID		01074	04102
Ensembl ID		ENSG00000120949	ENSG00000011021
Uniprot IDs		A5D8T4 P28908	P51797
PDB IDs		1D01	8JPJ 8JPO 8JPR
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation	Positive Regulation Of TRAIL Production Regulation Of TRAIL Production Transmembrane Signaling Receptor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Immature T Cell Proliferation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB4 Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Immature T Cell Proliferation In Thymus Semaphorin Receptor Complex Negative Regulation Of Cell Population Proliferation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Motor Neuron Axon Guidance Peripheral Nervous System Development Regulation Of T Cell Differentiation In Thymus ERBB2 Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Rho Protein Signal Transduction Regulation Of Protein Targeting To Membrane Protein Localization To Postsynaptic Membrane Positive Regulation Of Transcription By RNA Polymerase I Myelin Sheath Protein Localization To Postsynapse Positive Regulation Of MAP Kinase Activity Neuromuscular Junction Development Positive Regulation Of Gene Expression Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Oligodendrocyte Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Transcription By RNA Polymerase I Response To Epidermal Growth Factor Semaphorin-plexin Signaling Pathway Receptor Localization To Synapse Negative Regulation Of T Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Negative Regulation Of T Cell Proliferation Protein Localization To Synapse
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