FBLN5 and COXFA4

Data Source: HiPPIP (Novel)

		FBLN5	COXFA4
Name		fibulin 5	cytochrome c oxidase associated subunit FA4
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex I Respiratory Chain Complex IV
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Proton Transmembrane Transport
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs		None	NADH
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	None
GWAS		Diastolic blood pressure ( 30578418 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883 ) Heel bone mineral density ( 30598549 ) Height ( 18391951 25429064 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Major depressive disorder ( 34099189 ) Major depressive disorder x sex interaction ( 34099189 ) Optic disc size ( 31809533 ) Pulse pressure ( 27841878 30578418 ) Waist circumference adjusted for body mass index ( 28552196 )	No GWAS studies recorded
Novel Interactors		10 novel interactors: COXFA4 GSC LGMN PDIA3 PPP2R5C PSMC1 SERPINA1 SERPINA5 ST3GAL3 XCL1	1 novel interactors: FBLN5
Interacting Genes		13 interacting genes: ATN1 GFI1B HOXA1 LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13	2 interacting genes: APP PARK7
Entrez ID		10516	4697
HPRD ID		05204	04831
Ensembl ID		ENSG00000140092	ENSG00000189043
Uniprot IDs		A0A024R6G3 A0A9L9PXD9 G3V2P8 G3V4U0 G3XA98 Q9UBX5	O00483
PDB IDs		Not available	5Z62
GO Terms Enriched among Interactors		Copper Ion Binding Nuclear Matrix Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Heparin Binding Plasma Lipoprotein Particle Diencephalon Morphogenesis Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protease Binding Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Glycosaminoglycan Binding Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Type 8 Metabotropic Glutamate Receptor Binding Dendritic Spine Organization Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis RNA Topoisomerase Activity Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Negative Regulation Of Type II Interferon Production Postsynapse Organization	Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Activator Activity Regulation Of Superoxide Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Adult Locomotory Behavior Regulation Of Response To Calcium Ion Cell Body Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Protein Homodimerization Activity Peptidase Inhibitor Activity Regulation Of Cellular Response To Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Intramembranous Bone Growth Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity Integrin Binding Positive Regulation Of Apoptotic Signaling Pathway Adult Behavior Regulation Of Protein Localization To Nucleus Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Acetylcholine Receptor Activator Activity Membrane Raft PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Protein Localization Positive Regulation Of Endothelin Production Growth Cone Filopodium