SEC24B and SCAP

Number of citations of the paper that reports this interaction (PubMedID 19706601)
35

Data Source:
BioGRID (pull down)

		SEC24B	SCAP
Description		SEC24 homolog B, COPII component	SREBF chaperone
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP Complex Protein-containing Complex
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Lipid Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding
	Biological Process	Neural Tube Closure Auditory Receptor Cell Morphogenesis Outflow Tract Morphogenesis Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Cochlear Nucleus Development Aorta Morphogenesis Auditory Receptor Cell Stereocilium Organization Lung Morphogenesis Lung Lobe Morphogenesis Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Circulatory System Development COPII-coated Vesicle Cargo Loading Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Cargo Loading Into COPII-coated Vesicle	Response To Hypoxia Lipid Metabolic Process Immune Response Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Insulin SREBP Signaling Pathway Response To Vitamin B3 Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Late-onset Alzheimer's disease ( 27770636)	Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: SCAP SEC23A	5 interacting genes: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2
Entrez ID		10427	22937
HPRD ID		06216	03300
Ensembl ID		ENSG00000138802	ENSG00000114650
Uniprot IDs		B4DTM6 O95487	B7Z6H0 Q12770
PDB IDs		3EH1	6M49 7ETW
Enriched GO Terms of Interacting Partners?		COPII-coated Vesicle Cargo Loading Vesicle Cargo Loading ER To Golgi Transport Vesicle Membrane SREBP-SCAP Complex Response To Vitamin B3 COPII-coated Vesicle Budding Sterol Binding Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Golgi Membrane Response To Sterol Depletion COPII Vesicle Coat Cytoplasmic Vesicle Positive Regulation Of Cholesterol Biosynthetic Process Vesicle Budding From Membrane Endoplasmic Reticulum Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum Exit Site Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Intracellular Transport Positive Regulation Of Steroid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell Response To Vitamin Regulation Of Steroid Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Unfolded Protein Binding Cholesterol Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Sterol Metabolic Process Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Response To Nutrient Positive Regulation Of Small Molecule Metabolic Process Response To Insulin	SREBP-SCAP-Insig Complex SREBP Signaling Pathway Cellular Response To Sterol Depletion Response To Sterol Depletion Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cargo Loading Into COPII-coated Vesicle Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Biosynthetic Process ER-nucleus Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum Positive Regulation Of Steroid Metabolic Process Negative Regulation Of SREBP Signaling Pathway Regulation Of Cholesterol Metabolic Process Cranial Suture Morphogenesis Regulation Of SREBP Signaling Pathway Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Lipid Biosynthetic Process Oxysterol Binding Regulation Of Steroid Metabolic Process Craniofacial Suture Morphogenesis Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Middle Ear Morphogenesis Positive Regulation Of Lipid Metabolic Process NLS-bearing Protein Import Into Nucleus Negative Regulation Of Steroid Biosynthetic Process Embryonic Morphogenesis Positive Regulation Of Small Molecule Metabolic Process Lung Morphogenesis Negative Regulation Of Steroid Metabolic Process Cholesterol Biosynthetic Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Sterol Biosynthetic Process Maintenance Of Protein Localization In Organelle Protein Sequestering Activity Regulation Of Fatty Acid Biosynthetic Process Steroid Metabolic Process Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Maintenance Of Protein Location In Cell Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Vacuole-isolation Membrane Contact Site ER To Golgi Transport Vesicle Membrane Inner Ear Morphogenesis Triglyceride Metabolic Process Alcohol Metabolic Process Maintenance Of Protein Location
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