SEC24B and SCAP

Number of citations of the paper that reports this interaction (PMID 19706601)
8

Data Source:
BioGRID (pull down)

		SEC24B	SCAP
Gene Name		SEC24 family member B	SREBF chaperone
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex
	Molecular Function	Transporter Activity Protein Binding Zinc Ion Binding	Protein Binding Cholesterol Binding Protein Complex Binding Unfolded Protein Binding
	Biological Process	Neural Tube Closure Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Outflow Tract Morphogenesis Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cochlear Nucleus Development Aorta Morphogenesis Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process COPII Vesicle Coating Auditory Receptor Cell Stereocilium Organization Lung Lobe Morphogenesis Coronary Artery Morphogenesis Membrane Organization Pulmonary Artery Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Cargo Loading Into COPII-coated Vesicle	Response To Hypoxia Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation COPII (Coat Protein 2) Mediated Vesicle Transport ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System	Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: SCAP SEC23A	5 interactors: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2
Entrez ID		10427	22937
HPRD ID		06216	03300
Ensembl ID		ENSG00000138802	ENSG00000114650
Uniprot IDs		B7ZKM8 O95487	F8W921 Q12770
PDB IDs		3EH1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process SREBP Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Response To Sterol Depletion Regulation Of Receptor Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process COPII Vesicle Coating COPII-coated Vesicle Budding Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Vesicle Targeting, To, From Or Within Golgi Regulation Of Fatty Acid Biosynthetic Process Localization Within Membrane Vesicle Targeting Negative Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Membrane Budding Regulation Of Fatty Acid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Steroid Metabolic Process ER To Golgi Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Vascular Endothelial Growth Factor Receptor Signaling Pathway ER-nucleus Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cholesterol Metabolic Process Small Molecule Metabolic Process Protein N-linked Glycosylation Sterol Metabolic Process Regulation Of Lipid Biosynthetic Process	Regulation Of Cargo Loading Into COPII-coated Vesicle Inner Ear Morphogenesis Cholesterol Metabolic Process Ear Morphogenesis Sterol Metabolic Process Cranial Suture Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process SREBP Signaling Pathway Response To Sterol Depletion Craniofacial Suture Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Inner Ear Development Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Ear Development Negative Regulation Of Steroid Metabolic Process Middle Ear Morphogenesis Steroid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Embryonic Organ Morphogenesis Alcohol Metabolic Process Sterol Biosynthetic Process Negative Regulation Of Lipid Biosynthetic Process Embryonic Organ Development Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Sensory Organ Development Triglyceride Metabolic Process Regulation Of Steroid Metabolic Process Embryonic Morphogenesis Neutral Lipid Metabolic Process ER-nucleus Signaling Pathway Palate Development Steroid Biosynthetic Process Bone Morphogenesis Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Small Molecule Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Cellular Lipid Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cochlear Nucleus Development Bone Development Negative Regulation Of Cholesterol Efflux Embryo Development Pulmonary Artery Morphogenesis
Tagcloud ?		cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth golgi haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles	acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous
Tagcloud (Difference) ?		cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth golgi haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles	acanthosis acuminatum atypia buttock coincidental cuboidal dense dermis endophytic epidermis hyperkeratosis hyperkeratotic infiltrate keratotic koilocytotic lined nevus ns overlying papillae papillary papilliferum papillomatosis plasmacytic probes sebaceus stroma syringocystadenoma verrucous
Tagcloud (Intersection) ?