SEC24B and SEC23A

Number of citations of the paper that reports this interaction (PubMedID 10075675)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SEC24B	SEC23A
Description		SEC24 homolog B, COPII component	SEC23 homolog A, COPII component
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Auditory Receptor Cell Morphogenesis Outflow Tract Morphogenesis Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Cochlear Nucleus Development Aorta Morphogenesis Auditory Receptor Cell Stereocilium Organization Lung Morphogenesis Lung Lobe Morphogenesis Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Circulatory System Development COPII-coated Vesicle Cargo Loading Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Cargo Loading Into COPII-coated Vesicle	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Late-onset Alzheimer's disease ( 27770636)	Metabolite levels ( 23823483) Vitamin D levels ( 29343764)
Interacting Genes		2 interacting genes: SCAP SEC23A	33 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23IP SEC24B SEC24C SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11
Entrez ID		10427	10484
HPRD ID		06216	06714
Ensembl ID		ENSG00000138802	ENSG00000100934
Uniprot IDs		B4DTM6 O95487	Q15436
PDB IDs		3EH1	2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO 8HR0
Enriched GO Terms of Interacting Partners?		COPII-coated Vesicle Cargo Loading Vesicle Cargo Loading ER To Golgi Transport Vesicle Membrane SREBP-SCAP Complex Response To Vitamin B3 COPII-coated Vesicle Budding Sterol Binding Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Golgi Membrane Response To Sterol Depletion COPII Vesicle Coat Cytoplasmic Vesicle Positive Regulation Of Cholesterol Biosynthetic Process Vesicle Budding From Membrane Endoplasmic Reticulum Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum Exit Site Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Intracellular Transport Positive Regulation Of Steroid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell Response To Vitamin Regulation Of Steroid Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Unfolded Protein Binding Cholesterol Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Sterol Metabolic Process Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Response To Nutrient Positive Regulation Of Small Molecule Metabolic Process Response To Insulin	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Protein Localization To Endoplasmic Reticulum Exit Site Vesicle Cargo Loading Protein Localization To Endoplasmic Reticulum ER To Golgi Transport Vesicle Membrane COPII-coated Vesicle Cargo Loading Vesicle-mediated Transport Membrane Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Intracellular Transport Regulation Of Plasma Membrane Organization COPII Vesicle Coat Lipoprotein Transport Establishment Of Protein Localization Positive Regulation Of Mitochondrial Fission Mitochondrial Calcium Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Protein Transport
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