SEC24B

Description		SEC24 homolog B, COPII component
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Endoplasmic Reticulum Exit Site
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Auditory Receptor Cell Morphogenesis Outflow Tract Morphogenesis Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Cochlear Nucleus Development Aorta Morphogenesis Auditory Receptor Cell Stereocilium Organization Lung Morphogenesis Lung Lobe Morphogenesis Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Circulatory System Development COPII-coated Vesicle Cargo Loading Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Cargo Loading Into COPII-coated Vesicle
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		2 interacting genes: SCAP SEC23A
Entrez ID		10427
HPRD ID		06216
Ensembl ID		ENSG00000138802
Uniprot IDs		B4DTM6 O95487
PDB IDs		3EH1
Enriched GO Terms of Interacting Partners?		COPII-coated Vesicle Cargo Loading Vesicle Cargo Loading ER To Golgi Transport Vesicle Membrane SREBP-SCAP Complex Response To Vitamin B3 COPII-coated Vesicle Budding Sterol Binding Negative Regulation Of Cholesterol Biosynthetic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Cellular Response To Sterol Depletion Golgi Membrane Response To Sterol Depletion COPII Vesicle Coat Cytoplasmic Vesicle Positive Regulation Of Cholesterol Biosynthetic Process Vesicle Budding From Membrane Endoplasmic Reticulum Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum Exit Site Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Intracellular Transport Positive Regulation Of Steroid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell Response To Vitamin Regulation Of Steroid Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Unfolded Protein Binding Cholesterol Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Sterol Metabolic Process Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Response To Nutrient Positive Regulation Of Small Molecule Metabolic Process Response To Insulin
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