PIBF1 and MAP3K2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PIBF1	MAP3K2
Gene Name		progesterone immunomodulatory binding factor 1	mitogen-activated protein kinase kinase kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process		Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP MAP3K2	25 interactors: BIRC2 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K3 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 UBC USP2 WNK1 XIAP YWHAE YWHAG YWHAZ
Entrez ID		10464	10746
HPRD ID		06337	10068
Ensembl ID		ENSG00000083535	ENSG00000169967
Uniprot IDs		Q8WXW3	Q9Y2U5
PDB IDs			2CU1 2NPT
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Regulation Of Phosphorylation Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Activation Of JUN Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Biosynthetic Process Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Activation Of MAPKK Activity Visual Behavior Neuron Death Platelet Degranulation	Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Signal Transduction Intracellular Signal Transduction Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Toll-like Receptor Signaling Pathway Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Death Cell Communication Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Cellular Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity JNK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Cellular Response To Stress Regulation Of Catalytic Activity
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