ZNF511 and ISL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ZNF511	ISL1
Description		zinc finger protein 511	ISL LIM homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Nuclear Receptor Binding LIM Domain Binding Nuclear Estrogen Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Heart Morphogenesis Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Axonogenesis Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial To Mesenchymal Transition Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Cell Differentiation Neuron Differentiation Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Mesenchymal Cell Differentiation Stem Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Canonical Wnt Signaling Pathway Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Sinoatrial Node Cell Development Cellular Response To Glucocorticoid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Mesenchymal Cell Proliferation Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Calcium Ion Import Positive Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of expression of SLITs and ROBOs Cardiogenesis
Drugs
Diseases
GWAS		Nonunion in individuals with fractures ( 30680360)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol use disorder (consumption score) ( 30940813) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Childhood ear infection ( 27182965) Classic bladder exstrophy ( 25763902) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Diastolic blood pressure ( 27841878) Emotional lability in attention deficit hyperactivity disorder ( 31085060) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Verbal declarative memory ( 25648963) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		14 interacting genes: BOLA2 BOLA2B CFAP206 CLCNKA ENKD1 HSF2BP ISL1 KAT5 LHX2 LMO1 MAD2L2 NTAQ1 SCNM1 SMARCD1	21 interacting genes: APP CDK6 CDKN2B CRK ESR1 HNF4A ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LMO2 LMX1A NR2F1 PECR PLCG2 RELA RLIM SMAD3 ZNF511
Entrez ID		118472	3670
HPRD ID		15812	02650
Ensembl ID		ENSG00000198546	ENSG00000016082
Uniprot IDs		Q8NB15	P61371
PDB IDs
Enriched GO Terms of Interacting Partners?		Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly Negative Regulation Of Cell Differentiation Positive Regulation Of Double-strand Break Repair Regulation Of Sister Chromatid Segregation Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Regulation Of Chromosome Segregation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination 2 Iron, 2 Sulfur Cluster Binding Iron-sulfur Cluster Assembly Negative Regulation Of Developmental Process Chromatin Binding Regulation Of Lymphocyte Activation Positive Regulation Of Myoblast Differentiation Regulation Of DNA Repair Negative Regulation Of DNA Repair Double-strand Break Repair Negative Regulation Of DNA Recombination DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Double-strand Break Repair Establishment Of Mitotic Spindle Localization Histone H2AK5 Acetyltransferase Activity Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Orientation Protein-N-terminal Glutamine Amidohydrolase Activity A Axonemal Microtubule Cell Redox Homeostasis Regulation Of Chromosome Organization Establishment Of Spindle Localization Spindle Localization Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Binding Transcription Coactivator Activity Regulation Of Cell Activation Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Myoblast Differentiation Positive Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Visceral Motor Neuron Differentiation Positive Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production	Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MiRNA Transcription Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Transcription Coactivator Binding Central Nervous System Neuron Differentiation Response To Yeast Regulation Of Metabolic Process Cell Differentiation Chromatin Binding DNA Binding Regulation Of MiRNA Transcription Nucleus DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Developmental Process Regulation Of Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation In Spinal Cord
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?