ZNF511 and CLCNKA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF511	CLCNKA
Description		zinc finger protein 511	chloride voltage-gated channel Ka
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription	Monoatomic Ion Transport Chloride Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Renal Absorption Chloride Transmembrane Transport
Pathways			Stimuli-sensing channels
Drugs			Niflumic acid Talniflumate
Diseases			Bartter syndrome
GWAS		Nonunion in individuals with fractures ( 30680360)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		14 interacting genes: BOLA2 BOLA2B CFAP206 CLCNKA ENKD1 HSF2BP ISL1 KAT5 LHX2 LMO1 MAD2L2 NTAQ1 SCNM1 SMARCD1	22 interacting genes: CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SPMIP4 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511
Entrez ID		118472	1187
HPRD ID		15812	03608
Ensembl ID		ENSG00000198546	ENSG00000186510
Uniprot IDs		Q8NB15	P51800
PDB IDs			2PFI
Enriched GO Terms of Interacting Partners?		Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly Negative Regulation Of Cell Differentiation Positive Regulation Of Double-strand Break Repair Regulation Of Sister Chromatid Segregation Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Regulation Of Chromosome Segregation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination 2 Iron, 2 Sulfur Cluster Binding Iron-sulfur Cluster Assembly Negative Regulation Of Developmental Process Chromatin Binding Regulation Of Lymphocyte Activation Positive Regulation Of Myoblast Differentiation Regulation Of DNA Repair Negative Regulation Of DNA Repair Double-strand Break Repair Negative Regulation Of DNA Recombination DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Double-strand Break Repair Establishment Of Mitotic Spindle Localization Histone H2AK5 Acetyltransferase Activity Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Orientation Protein-N-terminal Glutamine Amidohydrolase Activity A Axonemal Microtubule Cell Redox Homeostasis Regulation Of Chromosome Organization Establishment Of Spindle Localization Spindle Localization Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Binding Transcription Coactivator Activity Regulation Of Cell Activation Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Myoblast Differentiation Positive Regulation Of DNA Recombination Positive Regulation Of RNA Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Visceral Motor Neuron Differentiation Positive Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epidermis Development Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Establishment Of Skin Barrier DNA-binding Transcription Factor Activity Type II Interferon Binding Coated Vesicle Membrane Skin Epidermis Development Cellular Developmental Process Tissue Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skin Development E-box Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein K33-linked Ubiquitination
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