TESK2 and CFL1

Number of citations of the paper that reports this interaction (PMID 9655398)
225

Data Source:
HPRD (in vivo, in vitro)

		TESK2	CFL1
Gene Name		testis-specific kinase 2	cofilin 1 (non-muscle)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Actin Binding Protein Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Focal Adhesion Assembly	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Platelet Degranulation Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Rho Protein Signal Transduction Axon Guidance Blood Coagulation Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Response To Amino Acid Innate Immune Response Negative Regulation Of Cell Size Ephrin Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis
Pathways			Axon guidance Semaphorin interactions Platelet degranulation EPHB-mediated forward signaling Response to elevated platelet cytosolic Ca2+ Sema3A PAK dependent Axon repulsion EPH-Ephrin signaling Platelet activation, signaling and aggregation Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Breast cancer ( 23535729) DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		3 interactors: CFL1 DSTN YWHAB	37 interactors: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		10420	1072
HPRD ID		05298	03261
Ensembl ID		ENSG00000070759	ENSG00000172757
Uniprot IDs		D3DPZ7 F5GWP9 Q96S53	P23528
PDB IDs			1Q8G 1Q8X 3J0S 4BEX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Organelle Organization Regulation Of Actin Filament Depolymerization Actin Polymerization Or Depolymerization Regulation Of Protein Depolymerization Regulation Of Organelle Organization Regulation Of Protein Complex Disassembly Cellular Protein Complex Disassembly Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Protein Complex Disassembly Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Actin Filament Organization Regulation Of Cellular Component Size Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Protein Dephosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Actin Filament-based Process Protein Targeting Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Axonogenesis Negative Regulation Of Cell Size Axon Development Neural Fold Formation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Chemotaxis Small GTPase Mediated Signal Transduction Actin Filament-based Process Neuron Projection Morphogenesis Actin Filament Severing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cytoplasmic Sequestering Of Protein Innate Immune Response Neuron Projection Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Response To Organonitrogen Compound Cell Projection Morphogenesis	Generation Of Neurons Neurogenesis Developmental Process Nervous System Development System Development Multicellular Organismal Development Phosphate-containing Compound Metabolic Process Regulation Of Organelle Organization Cell Differentiation Positive Regulation Of Organelle Organization Anatomical Structure Development Actin Cytoskeleton Organization Cellular Component Assembly Actin Filament-based Process Immune Response-regulating Signaling Pathway Platelet Activation Actomyosin Structure Organization Regulation Of Neurogenesis Anatomical Structure Morphogenesis MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Neuron Differentiation Cell Development Response To Stimulus Axon Guidance Phosphorylation Negative Regulation Of Catalytic Activity Cell Morphogenesis Involved In Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stress Homeostatic Process Regulation Of Axonogenesis Regulation Of Cell Development Signal Transduction By Phosphorylation Neuron Projection Morphogenesis Organelle Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myofibril Assembly Cell Activation Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Organization Neuron Development Adherens Junction Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Apoptotic Process
Tagcloud ?			anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?			anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?