TESK2 and DSTN

Number of citations of the paper that reports this interaction (PMID 11418599)
18

Data Source:
HPRD (in vitro)

		TESK2	DSTN
Gene Name		testis-specific kinase 2	destrin (actin depolymerizing factor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Actin Cytoskeleton Cortical Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Actin Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Focal Adhesion Assembly	Movement Of Cell Or Subcellular Component Actin Polymerization Or Depolymerization Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Actin Filament Severing
Pathways
Drugs
Diseases
GWAS			Presence of antiphospholipid antibodies ( 23509613)
Protein-Protein Interactions		3 interactors: CFL1 DSTN YWHAB	8 interactors: ACTB ACTG1 CFL2 SHBG SMAD9 SSH1 TAX1BP1 TESK2
Entrez ID		10420	11034
HPRD ID		05298	16446
Ensembl ID		ENSG00000070759	ENSG00000125868
Uniprot IDs		D3DPZ7 F5GWP9 Q96S53	P60981
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Organelle Organization Regulation Of Actin Filament Depolymerization Actin Polymerization Or Depolymerization Regulation Of Protein Depolymerization Regulation Of Organelle Organization Regulation Of Protein Complex Disassembly Cellular Protein Complex Disassembly Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Protein Complex Disassembly Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Actin Filament Organization Regulation Of Cellular Component Size Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Protein Dephosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Actin Filament-based Process Protein Targeting Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Axonogenesis Negative Regulation Of Cell Size Axon Development Neural Fold Formation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Chemotaxis Small GTPase Mediated Signal Transduction Actin Filament-based Process Neuron Projection Morphogenesis Actin Filament Severing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cytoplasmic Sequestering Of Protein Innate Immune Response Neuron Projection Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Response To Organonitrogen Compound Cell Projection Morphogenesis	Adherens Junction Organization Actin Cytoskeleton Organization Cell Junction Assembly Actin Filament-based Process Cell-cell Junction Organization Platelet Aggregation Sarcomere Organization Retina Homeostasis Myofibril Assembly Cytoskeleton Organization Primary Spermatocyte Growth Midbrain Development Nervous System Development Ephrin Receptor Signaling Pathway Anatomical Structure Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Generation Of Neurons Striated Muscle Cell Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Neurogenesis Muscle Cell Development Anatomical Structure Development Tissue Homeostasis Organelle Organization Platelet Activation Cell Development Innate Immune Response Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cellular Component Assembly Cell Differentiation Striated Muscle Cell Differentiation Mullerian Duct Regression Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Homeostasis Developmental Process Cellular Response To ATP Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Positive Regulation Of Actin Filament Depolymerization Muscle Cell Differentiation Regulation Of Cellular Component Size Homotypic Cell-cell Adhesion System Development Single Organism Reproductive Process
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