TESK2 and DSTN

Number of citations of the paper that reports this interaction (PubMedID 11418599)
0

Data Source:
HPRD (in vitro)

		TESK2	DSTN
Description		testis associated actin remodelling kinase 2	destrin, actin depolymerizing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Cytoplasm Actin Cytoskeleton Cortical Actin Cytoskeleton Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Focal Adhesion Assembly	Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Cell Motility Actin Filament Severing
Pathways
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494)	Coronary artery disease ( 29212778) Presence of antiphospholipid antibodies ( 23509613)
Interacting Genes		3 interacting genes: CFL1 DSTN YWHAB	10 interacting genes: ACTB ACTG1 CFTR FNDC3B SHBG SMAD9 SSH1 TAX1BP1 TESK2 VHL
Entrez ID		10420	11034
HPRD ID		05298	16446
Ensembl ID		ENSG00000070759	ENSG00000125868
Uniprot IDs		B4DFN2 Q96S53	P60981 V9HWA6
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament Fragmentation Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Actin Filament Severing Positive Regulation Of Protein Depolymerization Positive Regulation Of Protein-containing Complex Disassembly Protein Depolymerization Regulation Of Actin Filament Depolymerization Actin Polymerization Or Depolymerization Cortical Actin Cytoskeleton Regulation Of Protein Depolymerization Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Protein Localization To Cell Leading Edge Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Protein-containing Complex Disassembly Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Postsynaptic Density Organization Actin Filament Binding Regulation Of Protein Localization To Cell Leading Edge Actin Filament Organization Regulation Of Actin Filament Organization Neural Fold Formation Regulation Of Cellular Component Size Actin Cytoskeleton Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Lamellipodium Assembly Phosphoserine Residue Binding Regulation Of Actin Cytoskeleton Organization Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Negative Regulation Of Cell Size Actin Filament-based Process Positive Regulation Of Synaptic Plasticity Extracellular Exosome Focal Adhesion Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Ether Modification Of Postsynaptic Actin Cytoskeleton Phosphatidylinositol Bisphosphate Binding Regulation Of Dendritic Spine Maintenance Supramolecular Fiber Organization Vacuolar Membrane	Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Postsynaptic Cytoskeleton Organization Actin Filament-based Process Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Actin Cytoskeleton Organization Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Platelet Aggregation Cell Junction Assembly Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Homotypic Cell-cell Adhesion Basal Body Patch Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Localization To Cell Junction Actin Filament Regulation Of Norepinephrine Uptake Positive Regulation Of Anion Channel Activity Protein Localization To Phagocytic Vesicle Positive Regulation Of AMPA Glutamate Receptor Clustering Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Cytoskeleton Organization Transporter Regulator Activity Positive Regulation Of Monoatomic Anion Transport Cell-cell Junction Assembly Cytoplasm Blood Microparticle Cell Junction Organization Multicellular Organismal-level Homeostasis Positive Regulation Of Enamel Mineralization Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Postsynaptic Membrane Organization Regulation Of Cellular Localization Protein Localization To Adherens Junction Transepithelial Water Transport Androgen Binding Response To Purine-containing Compound Regulation Of Vesicle-mediated Transport
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