HPCAL4 and AQP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HPCAL4	AQP4
Description		hippocalcin like 4	aquaporin 4
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Sarcolemma Cell Projection Astrocyte End-foot
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding Water Channel Activity Channel Activity Identical Protein Binding
	Biological Process	Central Nervous System Development Response To Heat Regulation Of Signal Transduction	Renal Water Homeostasis Water Transport Intracellular Water Homeostasis Multicellular Organismal-level Water Homeostasis Protein Homotetramerization Transmembrane Transport Cellular Response To Type II Interferon Cerebrospinal Fluid Circulation
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS		Bone mineral density (Ward's triangle area) ( 27397699)	Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A	7 interacting genes: AP2M1 AP3M1 CREB3 CSNK2A1 CSNK2A2 GJA8 HPCAL4
Entrez ID		51440	361
HPRD ID		17113	02631
Ensembl ID		ENSG00000116983	ENSG00000171885
Uniprot IDs		B4DGW9 Q9UM19	A0A5F9ZHR4 F1DSG4 P55087 V9PBN7
PDB IDs			3GD8 8V8S 8V91 8V9D
Enriched GO Terms of Interacting Partners?			Protein Kinase CK2 Complex Postsynaptic Neurotransmitter Receptor Internalization Clathrin Adaptor Complex PcG Protein Complex Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Vacuole Receptor Internalization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Positive Regulation Of Deacetylase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Vesicle-mediated Transport In Synapse Protein Localization To Vacuole Intracellular Protein Transport Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Positive Regulation Of Aggrephagy Release From Viral Latency Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Gap Junction-mediated Intercellular Transport CCR1 Chemokine Receptor Binding Postsynaptic Recycling Endosome Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Double-strand Break Repair Negative Regulation Of Apoptotic Process Intercellular Transport CAMP Response Element Binding Protein Binding AP-2 Adaptor Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Negative Regulation Of Programmed Cell Death AP-3 Adaptor Complex Wnt Signaling Pathway Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
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