HPCAL4 and DTX2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		HPCAL4	DTX2
Gene Name		hippocalcin like 4	deltex 2, E3 ubiquitin ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein C-terminus Binding Protein Domain Specific Binding	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Signal Transduction Central Nervous System Development	Notch Signaling Pathway Protein Ubiquitination
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DTX2 FAM131C TSC22D3 TTC12 UBE3A	41 interactors: ABHD16A ALKBH4 ARNT2 C1orf94 DTX1 DTX3 EIF4ENIF1 FAM168A FHL2 GLYCTK GOLGA2 HDC HPCAL1 HPCAL4 KLC3 KRTAP26-1 MDC1 NCALD NCS1 NOTCH1 PLEKHF2 PLSCR1 QARS RBPMS RFX6 RHOXF2 RIMBP3 SEC22A SEC23B SPAG8 SPG21 STX12 SUMO1 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D3 UBE2D4 UBQLN4 VSNL1
Entrez ID		51440	113878
HPRD ID		17113	16841
Ensembl ID		ENSG00000116983	ENSG00000091073
Uniprot IDs		B4DGW9 Q9UM19	Q86UW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm Entry Negative Regulation Of Activation-induced Cell Death Of T Cells Regulation Of Activation-induced Cell Death Of T Cells Negative Regulation Of Skeletal Muscle Tissue Development Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of T Cell Apoptotic Process Prostate Gland Growth	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transcription, DNA-templated RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Innate Immune Response Protein K11-linked Ubiquitination RNA Metabolic Process Cellular Response To Oxygen Levels Heart Trabecula Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Hypoxia Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Notch Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stimulus Cellular Nitrogen Compound Metabolic Process Pancreatic Epsilon Cell Differentiation Glutaminyl-tRNA Aminoacylation Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Pancreatic D Cell Differentiation Cleavage Furrow Ingression Protein Ubiquitination Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Glandular Epithelial Cell Differentiation Signal Transduction Trabecula Morphogenesis Positive Regulation Of Innate Immune Response Vesicle Fusion Regulation Of Immune System Process Prolyl-tRNA Aminoacylation Vasculogenesis Involved In Coronary Vascular Morphogenesis Cardiac Right Atrium Morphogenesis Mitral Valve Formation Histamine Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		1p 1p11 1p34 affymetrix amplifications analysing arm arrays artificial bmp8 coinciding fine fingerprint heyl ipt kb mapping mb megabase oligonucleotide oncogenes ordered p34 pheochromocytoma rlf segmental semiquantitative spanning suppressors	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx1 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Difference) ?		1p 1p11 1p34 affymetrix amplifications analysing arm arrays artificial bmp8 coinciding fine fingerprint heyl ipt kb mapping mb megabase oligonucleotide oncogenes ordered p34 pheochromocytoma rlf segmental semiquantitative spanning suppressors	algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx1 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Intersection) ?