STOX1 and GCLM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		STOX1	GCLM
Description		storkhead box 1	glutamate-cysteine ligase modifier subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Cell Cortex	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Glutamate-cysteine Ligase Activity Protein Binding Glutamate-cysteine Ligase Catalytic Subunit Binding Protein-containing Complex Binding Glutamate-cysteine Ligase Regulator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Inner Ear Development Cell Division Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Nitrosative Stress Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitochondrial DNA Metabolic Process Regulation Of Response To Oxidative Stress Positive Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Otic Vesicle Morphogenesis	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Nutrient Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Response To Activity Cellular Response To Hepatocyte Growth Factor Stimulus Hepatic Stellate Cell Activation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Glutathione synthesis and recycling Defective GCLC causes HAGGSD NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Glutamic acid Cysteine
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hip circumference adjusted for BMI ( 34021172)	Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		8 interacting genes: ADARB1 AKT1 BANP GCLM GORASP2 NFYC POU2F1 ROR2	5 interacting genes: CALM1 CFTR IRF7 OSGIN1 STOX1
Entrez ID		219736	2730
HPRD ID		18579	03106
Ensembl ID		ENSG00000165730	ENSG00000023909
Uniprot IDs		Q6ZVD7	P48507
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Hypoglossal Nerve Morphogenesis Deaminase Activity TRNA-specific Adenosine Deaminase Activity Adenosine To Inosine Editing RNA Modification Adenosine Deaminase Activity Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric-oxide Synthase Regulator Activity Glucose Homeostasis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Negative Regulation Of Neuron Apoptotic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Apoptotic Mitochondrial Changes Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Transmembrane Transporter Activity Membrane Docking Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Otic Vesicle Morphogenesis Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization MDA-5 Signaling Pathway Cellular Response To Nitrosative Stress Positive Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transepithelial Water Transport Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Mitochondrial DNA Metabolic Process Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Autophagosome Membrane Docking Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Voltage-gated Calcium Channel Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Response To Nitrosative Stress Regulation Of Monoatomic Ion Transmembrane Transport Amelogenesis Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Multicellular Organismal Process
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