MYL12B and MYLIP

Number of citations of the paper that reports this interaction (PubMedID 10593918)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MYL12B	MYLIP
Description		myosin light chain 12B	myosin regulatory light chain interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Brush Border Cell Cortex Myosin Complex Myosin II Complex Myofibril Z Disc Protein-containing Complex Apical Part Of Cell Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Myosin Heavy Chain Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Cell Shape	Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Apolipoprotein B levels ( 32203549) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 20864672 24097068 25961943) LDL cholesterol levels ( 32203549 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)
Interacting Genes		5 interacting genes: DAPK1 HSPB1 MYLIP NSMF PNKD	42 interacting genes: ADAMTSL4 AR ARID5A CNPY2 CRK DAPP1 DDIT4L EFHC2 EXOSC5 FAM217B GMCL1 HOOK2 INO80B KANK4 KDM1A LDLR LNX2 LRP8 MIPOL1 MTAP MYL12B NHLRC4 NOXA1 NR1D2 PAX9 RASSF5 SCNM1 SDCBP SRPK2 TCEANC TSC1 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR ZBTB16 ZBTB18 ZBTB42 ZNF417 ZNF438
Entrez ID		103910	29116
HPRD ID		10095	17621
Ensembl ID		ENSG00000118680	ENSG00000007944
Uniprot IDs		O14950	Q5TIA5 Q8WY64
PDB IDs			2YHN 2YHO 6QLY 6QLZ
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Protein Kinase C Signaling Regulation Of NMDA Receptor Activity Plasma Membrane Protein Kinase C Inhibitor Activity Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Programmed Cell Death Cellular Response To Hydroperoxide Regulation Of Apoptotic Process Postsynaptic Density Defense Response To Tumor Cell Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Regulation Of Translation Regulation Of Autophagy Cytoskeleton Regulation Of Neurotransmitter Receptor Activity Syntaxin-1 Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Contractile Muscle Fiber Lactate Metabolic Process Methylglyoxal Metabolic Process Regulation Of Synaptic Transmission, Dopaminergic Aldehyde Catabolic Process Regulation Of Dopamine Metabolic Process Ketone Catabolic Process Cellular Detoxification Of Aldehyde Neuromuscular Process Controlling Posture Negative Regulation Of Neurotransmitter Secretion Apical Dendrite Regulation Of Neuron Projection Development Positive Regulation Of Neuron Migration Cellular Response To Electrical Stimulus Cellular Response To Gonadotropin Stimulus Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Refolding Presynaptic Cytosol	Very-low-density Lipoprotein Particle Receptor Activity Ubiquitin Conjugating Enzyme Activity Reelin-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Low-density Lipoprotein Particle Receptor Activity Reelin Receptor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Binding Cerebral Cortex Development Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Ventral Spinal Cord Development Negative Regulation Of Macromolecule Metabolic Process Nucleus Ubiquitin-protein Transferase Activity Protein-containing Complex Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Dendrite Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hippocampus Development Cellular Response To Estrogen Stimulus Identical Protein Binding Apolipoprotein Binding Regulation Of Low-density Lipoprotein Particle Clearance
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