MYL12B and MYLIP

Number of citations of the paper that reports this interaction (PMID 10593918)
16

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MYL12B	MYLIP
Gene Name		myosin, light chain 12B, regulatory	myosin regulatory light chain interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytosol Myosin II Complex Z Disc Apical Part Of Cell Extracellular Vesicular Exosome	Intracellular Cytoplasm Cytoskeleton Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Calcium Ion Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Muscle Contraction Axon Guidance Regulation Of Cell Shape Ephrin Receptor Signaling Pathway	Movement Of Cell Or Subcellular Component Nervous System Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions Smooth Muscle Contraction EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		3 interactors: DAPK1 MYLIP PNKD	15 interactors: CNPY2 KDM1A LDLR LRP8 MIPOL1 MTAP MYL12B RASSF5 TSC22D4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR
Entrez ID		103910	29116
HPRD ID		10095	17621
Ensembl ID		ENSG00000118680	ENSG00000007944
Uniprot IDs		O14950	Q5TIA5 Q8WY64
PDB IDs			2YHN 2YHO
Enriched GO Terms of Interacting Partners?		Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Posttranscriptional Regulation Of Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance Neuromuscular Process Controlling Posture Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Glutathione Biosynthetic Process Protein Destabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Peptide Biosynthetic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein K48-linked Ubiquitination Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Reelin-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Negative Regulation Of Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Response To Stimulus Positive Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations
Tagcloud (Difference) ?			aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations
Tagcloud (Intersection) ?